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gem gemini [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36064, updated on 9-Dec-2024

Summary

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Official Symbol
gemprovided by FlyBase
Official Full Name
geminiprovided by FlyBase
Primary source
FLYBASE:FBgn0050011
Locus tag
Dmel_CG30011
See related
AllianceGenome:FB:FBgn0050011
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-AE003830.1; BcDNA:HL07889; CG11867; CG30011; CG3459; dCP2; Dmel\CG30011; Gem
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including adult brain; cuboidal/columnar epithelium; embryonic/larval midgut primordium; gut section; and mesoderm. Orthologous to several human genes including TFCP2 (transcription factor CP2) and TFCP2L1 (transcription factor CP2 like 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See gem in Genome Data Viewer
Location:
46F1-46F2; 2-62 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10124293..10137472)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6011798..6024977)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene dampened Neighboring gene uncharacterized protein Neighboring gene Copper chaperone for superoxide dismutase Neighboring gene antisense RNA:CR43467 Neighboring gene uncharacterized protein Neighboring gene Odorant receptor 46a Neighboring gene uncharacterized protein Neighboring gene KCNQ potassium channel

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Knockdown of SCF(Skp2) function causes double-parked accumulation in the nucleus and DNA re-replication in Drosophila plasmatocytes. Kroeger PT Jr, et al. PLoS One, 2013. PMID 24205363, Free PMC Article
  2. A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead. Wilanowski T, et al. Mech Dev, 2002 Jun. PMID 12175488
  3. Tracheal development in Drosophila melanogaster as a model system for studying the development of a branched organ. Ebner A, et al. Gene, 2002 Apr 3. PMID 11992723
  4. Microarray analysis of the gene expression profiles of SL2 cells stimulated by LPS/PGN and curdlan. Jin LH, et al. Mol Cells, 2008 Jun 30. PMID 18460901
  5. Spotlight on the Granules (Grainyhead-Like Proteins) - From an Evolutionary Conserved Controller of Epithelial Trait to Pioneering the Chromatin Landscape. Sundararajan V, et al. Front Mol Biosci, 2020. PMID 32974388, Free PMC Article

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
gemini
Names
CG30011-PA
CG30011-PC
CG30011-PF
CG30011-PG
gem-PA
gem-PC
gem-PF
gem-PG
persephone

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    10124293..10137472
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136712.4 → NP_610556.1  gemini, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610556.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z851
    Related
    FBpp0088699
    Conserved Domains (2) summary
    cd09537
    Location:739 → 805
    SAM_CP2-like; SAM domain of CP2-like transcription factors
    pfam04516
    Location:393 → 624
    CP2; CP2 transcription factor

  2. NM_165750.4 → NP_724895.1  gemini, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724895.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E2QCN6, Q8SY59
    Related
    FBpp0088700
    Conserved Domains (2) summary
    cd09537
    Location:726 → 792
    SAM_CP2-like; SAM domain of CP2-like transcription factors
    pfam04516
    Location:380 → 611
    CP2; CP2 transcription factor

  3. NM_165748.3 → NP_724893.3  gemini, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724893.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    E2QCN6, Q8SY59
    Conserved Domains (2) summary
    cd09537
    Location:726 → 792
    SAM_CP2-like; SAM domain of CP2-like transcription factors
    pfam04516
    Location:380 → 611
    CP2; CP2 transcription factor

  4. NM_001299342.1 → NP_001286271.1  gemini, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286271.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LG06
    Conserved Domains (1) summary
    cd09537
    Location:77 → 143
    SAM_CP2-like; SAM domain of CP2-like transcription factors
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LG06 A0A0B4LG06
A1Z851 A1Z851
Q8SY59 Q8SY59
Q95RY5 Q95RY5

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