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dmpd dampened [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36061, updated on 4-Jan-2025

Summary

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Official Symbol
dmpdprovided by FlyBase
Official Full Name
dampenedprovided by FlyBase
Primary source
FLYBASE:FBgn0033486
Locus tag
Dmel_CG11866
See related
AllianceGenome:FB:FBgn0033486
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11866; Dmel\CG11866; FBXO13
Summary
Enables transcription coactivator activity. Involved in anterior/posterior pattern specification and positive regulation of DNA-templated transcription. Located in nucleus. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See dmpd in Genome Data Viewer
Location:
46F1-46F1; 2-62 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10117694..10121451)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6005199..6008956)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene 14-3-3zeta Neighboring gene Phosphofructokinase Neighboring gene Copper chaperone for superoxide dismutase Neighboring gene uncharacterized protein Neighboring gene gemini

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Time to move on: Modeling transcription dynamics during an embryonic transition away from maternal control. Liu J, et al. Fly (Austin), 2016 Jul 2. PMID 27172244, Free PMC Article
  2. Dampened regulates the activating potency of Bicoid and the embryonic patterning outcome in Drosophila. Liu J, et al. Nat Commun, 2013. PMID 24336107, Free PMC Article
  3. A matter of time: Formation and interpretation of the Bicoid morphogen gradient. Huang A, et al. Curr Top Dev Biol, 2020. PMID 32143754
  4. Tracheal development in Drosophila melanogaster as a model system for studying the development of a branched organ. Ebner A, et al. Gene, 2002 Apr 3. PMID 11992723
  5. A conserved F-box gene with unusual transcript localization. Das T, et al. Dev Genes Evol, 2002 Apr. PMID 11976951

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dmpd achieves its embryonic patterning role through regulating the activating potency of Bcd
    Title: Dampened regulates the activating potency of Bicoid and the embryonic patterning outcome in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISM
Inferred from Sequence Model
more info
  
involved_in anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex ISM
Inferred from Sequence Model
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
dampened
Names
CG11866-PA
CG11866-PB
dmpd-PA
dmpd-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    10117694..10121451
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259306.2 → NP_001246235.1  dampened, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246235.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K2J4
    Conserved Domains (1) summary
    pfam00646
    Location:122 → 156
    F-box; F-box domain

  2. NM_136711.4 → NP_610555.1  dampened, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610555.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K2J4
    Related
    FBpp0087509
    Conserved Domains (1) summary
    pfam00646
    Location:122 → 156
    F-box; F-box domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K2J4 Q7K2J4

Gene LinkOut

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