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Cdc2rk Cdc2-related kinase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36051, updated on 9-Dec-2024

Summary

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Official Symbol
Cdc2rkprovided by FlyBase
Official Full Name
Cdc2-related kinaseprovided by FlyBase
Primary source
FLYBASE:FBgn0013435
Locus tag
Dmel_CG1362
See related
AllianceGenome:FB:FBgn0013435
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cdc2rk; CG1362; Dcdrk; Dmel\CG1362
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in regulation of cell cycle. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in organism. Orthologous to human CDK10 (cyclin dependent kinase 10). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Cdc2rk in Genome Data Viewer
Location:
46E1-46E1; 2-62 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10067217..10068702, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5954722..5956207, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene magu Neighboring gene Defensin Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class N Neighboring gene mitochondrial ribosomal protein L42 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene snoRNA:Orphan H/ACA box 7 Neighboring gene eiger

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of a novel Drosophila gene encoding a Cdc2-related protein kinase. Sugaya R, et al. J Biochem, 1994 Jan. PMID 8188624
  2. Phosphorylation of Drosophila CENP-A on serine 20 regulates protein turn-over and centromere-specific loading. Huang A, et al. Nucleic Acids Res, 2019 Nov 18. PMID 31535131, Free PMC Article
  3. Evolution of cyclin-dependent kinases (CDKs) and CDK-activating kinases (CAKs): differential conservation of CAKs in yeast and metazoa. Liu J, et al. Mol Biol Evol, 2000 Jul. PMID 10889219
  4. Multiplexed conditional genome editing with Cas12a in Drosophila. Port F, et al. Proc Natl Acad Sci U S A, 2020 Sep 15. PMID 32843348, Free PMC Article
  5. Evolution of protein kinase signaling from yeast to man. Manning G, et al. Trends Biochem Sci, 2002 Oct. PMID 12368087

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cyclin-dependent protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of precatalytic spliceosome HDA PubMed 

General protein information

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Preferred Names
Cdc2-related kinase
Names
CG1362-PA
Cdc2rk-PA
cdc2-related-kinase
NP_523674.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    10067217..10068702 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078950.4 → NP_523674.1  Cdc2-related kinase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523674.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z840, C6SUX7
    Related
    FBpp0087515
    Conserved Domains (2) summary
    cd07845
    Location:45 → 353
    STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10
    smart00220
    Location:53 → 337
    S_TKc; Serine/Threonine protein kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z840 A1Z840
Q24294 Q24294
Q8IGS3 Q8IGS3

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