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Mpv17 mitochondrial inner membrane protein MPV17 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360463, updated on 4-Jan-2025

Summary

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Official Symbol
Mpv17provided by RGD
Official Full Name
mitochondrial inner membrane protein MPV17provided by RGD
Primary source
RGD:1310512
See related
EnsemblRapid:ENSRNOG00000049430 AllianceGenome:RGD:1310512
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mpv17l
Summary
Predicted to enable channel activity. Predicted to be involved in several processes, including cellular response to reactive oxygen species; glomerular basement membrane development; and regulation of mitochondrial DNA metabolic process. Predicted to act upstream of or within reactive oxygen species metabolic process and sensory perception of sound. Predicted to be located in mitochondrial inner membrane and peroxisome. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2EE and mitochondrial DNA depletion syndrome 6. Orthologous to human MPV17 (mitochondrial inner membrane protein MPV17). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Adrenal (RPKM 47.0), Thymus (RPKM 41.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mpv17 in Genome Data Viewer
Location:
6q14
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (30941693..30956389)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (25221668..25236241)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (26585713..26600265)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2B subunit delta Neighboring gene general transcription factor IIIC subunit 2 Neighboring gene tripartite motif-containing 54 Neighboring gene urocortin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Increased Expression of Mitochondrial Inner-Membrane Protein Mpv17 After Intracerebral Hemorrhage in Adult Rats. Li A, et al. Neurochem Res, 2015 Aug. PMID 26123482
  2. MPV17 Loss Causes Deoxynucleotide Insufficiency and Slow DNA Replication in Mitochondria. Dalla Rosa I, et al. PLoS Genet, 2016 Jan. PMID 26760297, Free PMC Article
  3. The Human Mitochondrial DNA Depletion Syndrome Gene MPV17 Encodes a Non-selective Channel That Modulates Membrane Potential. Antonenkov VD, et al. J Biol Chem, 2015 May 29. PMID 25861990, Free PMC Article
  4. MPV17 encodes an inner mitochondrial membrane protein and is mutated in infantile hepatic mitochondrial DNA depletion. Spinazzola A, et al. Nat Genet, 2006 May. PMID 16582910
  5. The glomerulosclerosis gene Mpv17 encodes a peroxisomal protein producing reactive oxygen species. Zwacka RM, et al. EMBO J, 1994 Nov 1. PMID 7957077, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mpv17 expression was increased after intracerebral hemorrhage.
    Title: Increased Expression of Mitochondrial Inner-Membrane Protein Mpv17 After Intracerebral Hemorrhage in Adult Rats.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables channel activity IEA
Inferred from Electronic Annotation
more info
  
enables channel activity ISO
Inferred from Sequence Orthology
more info
  
enables channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cellular response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
  
involved_in glomerular basement membrane development ISO
Inferred from Sequence Orthology
more info
  
involved_in homeostatic process IEA
Inferred from Electronic Annotation
more info
  
involved_in homeostatic process ISO
Inferred from Sequence Orthology
more info
  
involved_in inner ear development ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial genome maintenance IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial genome maintenance ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitochondrial DNA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitochondrial DNA metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mitochondrial DNA metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitochondrial DNA metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within sensory perception of sound ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
NOT located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitochondrial inner membrane protein Mpv17; protein Mpv17
Names
MPV17 mitochondrial membrane protein-like
MpV17 mitochondrial inner membrane protein
Mpv17 transgene, kidney disease mutant-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098240.1 → NP_001091710.1  mitochondrial inner membrane protein Mpv17

    See identical proteins and their annotated locations for NP_001091710.1

    Status: PROVISIONAL

    Source sequence(s)
    BC091193
    UniProtKB/Swiss-Prot
    Q5BK62
    UniProtKB/TrEMBL
    A0A8I6ADY6, A6HA73
    Related
    ENSRNOP00000037647.6, ENSRNOT00000034207.6
    Conserved Domains (1) summary
    pfam04117
    Location:109 → 170
    Mpv17_PMP22; Mpv17 / PMP22 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    30941693..30956389
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112437.2 → XP_038968365.1  protein Mpv17 isoform X1

    Conserved Domains (1) summary
    pfam04117
    Location:140 → 201
    Mpv17_PMP22; Mpv17 / PMP22 family

  2. XM_039112438.2 → XP_038968366.1  protein Mpv17 isoform X2

    Conserved Domains (1) summary
    pfam04117
    Location:140 → 190
    Mpv17_PMP22; Mpv17 / PMP22 family

  3. XM_063262038.1 → XP_063118108.1  protein Mpv17 isoform X5

    UniProtKB/TrEMBL
    A0A8I6ADY6, A0A8I6GJS1

  4. XM_063262042.1 → XP_063118112.1  protein Mpv17 isoform X8

  5. XM_039112445.2 → XP_038968373.1  protein Mpv17 isoform X5

    UniProtKB/TrEMBL
    A0A8I6ADY6, A0A8I6GJS1
    Conserved Domains (1) summary
    pfam04117
    Location:109 → 159
    Mpv17_PMP22; Mpv17 / PMP22 family

  6. XM_039112444.2 → XP_038968372.1  protein Mpv17 isoform X5

    UniProtKB/TrEMBL
    A0A8I6ADY6, A0A8I6GJS1
    Conserved Domains (1) summary
    pfam04117
    Location:109 → 159
    Mpv17_PMP22; Mpv17 / PMP22 family

  7. XM_063262040.1 → XP_063118110.1  protein Mpv17 isoform X6

  8. XM_063262039.1 → XP_063118109.1  protein Mpv17 isoform X6

    Related
    ENSRNOP00000092589.2, ENSRNOT00000102606.2

  9. XM_039112443.2 → XP_038968371.1  protein Mpv17 isoform X4

    UniProtKB/Swiss-Prot
    Q5BK62
    UniProtKB/TrEMBL
    A0A8I6ADY6, A6HA73
    Conserved Domains (1) summary
    pfam04117
    Location:109 → 170
    Mpv17_PMP22; Mpv17 / PMP22 family

  10. XM_039112441.2 → XP_038968369.1  protein Mpv17 isoform X4

    UniProtKB/Swiss-Prot
    Q5BK62
    UniProtKB/TrEMBL
    A0A8I6ADY6, A6HA73
    Conserved Domains (1) summary
    pfam04117
    Location:109 → 170
    Mpv17_PMP22; Mpv17 / PMP22 family

  11. XM_063262043.1 → XP_063118113.1  protein Mpv17 isoform X9

  12. XM_063262041.1 → XP_063118111.1  protein Mpv17 isoform X7

    UniProtKB/TrEMBL
    A0A8I6ADY6

  13. XM_039112440.2 → XP_038968368.1  protein Mpv17 isoform X4

    UniProtKB/Swiss-Prot
    Q5BK62
    UniProtKB/TrEMBL
    A0A8I6ADY6, A6HA73
    Conserved Domains (1) summary
    pfam04117
    Location:109 → 170
    Mpv17_PMP22; Mpv17 / PMP22 family

  14. XM_039112439.2 → XP_038968367.1  protein Mpv17 isoform X3

    UniProtKB/TrEMBL
    A0A8I6ADY6
    Conserved Domains (1) summary
    pfam04117
    Location:111 → 172
    Mpv17_PMP22; Mpv17 / PMP22 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5BK62.1 GenPept UniProtKB/Swiss-Prot:Q5BK62

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