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oys oysgedart [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36045, updated on 4-Jan-2025

Summary

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Official Symbol
oysprovided by FlyBase
Official Full Name
oysgedartprovided by FlyBase
Primary source
FLYBASE:FBgn0033476
Locus tag
Dmel_CG18445
See related
AllianceGenome:FB:FBgn0033476
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG18445; Dmel\CG18445; Oys
Summary
Enables lysophospholipid acyltransferase activity. Involved in several processes, including germ cell migration; lipid modification; and sperm individualization. Located in membrane. Is expressed in adult head; male germline cell; and organism. Orthologous to human MBOAT1 (membrane bound O-acyltransferase domain containing 1) and MBOAT2 (membrane bound O-acyltransferase domain containing 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See oys in Genome Data Viewer
Location:
46D7-46D8; 2-61 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10034595..10048619, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5922100..5936124, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44294 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44295 Neighboring gene uncharacterized protein Neighboring gene Cytochrome c oxidase subunit 7C Neighboring gene antisense RNA:CR44297 Neighboring gene Cytochrome c oxidase subunit 7C-like Neighboring gene seele Neighboring gene magu

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila lysophospholipid acyltransferases are specifically required for germ cell development. Steinhauer J, et al. Mol Biol Cell, 2009 Dec. PMID 19864461, Free PMC Article
  2. Drosophila spermatid individualization is sensitive to temperature and fatty acid metabolism. Ben-David G, et al. Spermatogenesis, 2015 Jan-Apr. PMID 26413411, Free PMC Article
  3. Drosophila Pif1A is essential for spermatogenesis and is the homolog of human CCDC157, a gene associated with idiopathic NOA. Yuan X, et al. Cell Death Dis, 2019 Feb 11. PMID 30741974, Free PMC Article
  4. Drosophila mini-white model system: new insights into positive position effects and the role of transcriptional terminators and gypsy insulator in transgene shielding. Silicheva M, et al. Nucleic Acids Res, 2010 Jan. PMID 19854952, Free PMC Article
  5. Drosophila model for studying the link between lipid metabolism and development. Thanh MT, et al. Front Biosci (Landmark Ed), 2020 Jan 1. PMID 31585882

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lysophospholipid acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in germ cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in lipid modification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid modification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in plasma membrane organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sperm individualization IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
oysgedart
Names
CG18445-PA
CG18445-PB
CG18445-PD
CG18445-PE
O-acyl transferase
oys-PA
oys-PB
oys-PD
oys-PE
NP_001286265.1
NP_001286266.1
NP_001286267.1
NP_610546.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    10034595..10048619 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299338.1 → NP_001286267.1  oysgedart, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286267.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0B4LG01, Q6NN55
    Conserved Domains (1) summary
    cl00738
    Location:22 → 484
    MBOAT; membrane-bound O-acyltransferase family

  2. NM_001299336.1 → NP_001286265.1  oysgedart, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286265.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0B4LG01, Q6NN55
    Conserved Domains (1) summary
    cl00738
    Location:22 → 484
    MBOAT; membrane-bound O-acyltransferase family

  3. NM_001299337.1 → NP_001286266.1  oysgedart, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286266.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LG01
    Conserved Domains (1) summary
    cl00738
    Location:4 → 464
    MBOAT; MBOAT, membrane-bound O-acyltransferase family

  4. NM_136702.3 → NP_610546.1  oysgedart, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610546.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0B4LG01, Q6NN55
    Related
    FBpp0087520
    Conserved Domains (1) summary
    cl00738
    Location:22 → 484
    MBOAT; membrane-bound O-acyltransferase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NN55.1 Q6NN55
Q8T8Q2 Q8T8Q2

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