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CG12129 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36044, updated on 9-Dec-2024

Summary

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Official Symbol
CG12129provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0033475
Locus tag
Dmel_CG12129
See related
AllianceGenome:FB:FBgn0033475
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg12129; Dmel\CG12129
Summary
Predicted to enable RNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in organism. Human ortholog(s) of this gene implicated in Barrett's esophagus. Orthologous to human ASCC1 (activating signal cointegrator 1 complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See CG12129 in Genome Data Viewer
Location:
46D7-46D7; 2-61 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10033304..10034698)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5920809..5922203)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44294 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene oysgedart Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44295

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Population-scale long-read sequencing uncovers transposable elements associated with gene expression variation and adaptive signatures in Drosophila. Rech GE, et al. Nat Commun, 2022 Apr 12. PMID 35413957, Free PMC Article
  2. Investigating the Evolution of Drosophila STING-Dependent Antiviral Innate Immunity by Multispecies Comparison of 2'3'-cGAMP Responses. Hédelin L, et al. Mol Biol Evol, 2024 Mar 1. PMID 38377349, Free PMC Article
  3. Identification of common and cell type specific LXXLL motif EcR cofactors using a bioinformatics refined candidate RNAi screen in Drosophila melanogaster cell lines. Davis MB, et al. BMC Dev Biol, 2011 Nov 3. PMID 22050674, Free PMC Article
  4. Detection of novel members, structure-function analysis and evolutionary classification of the 2H phosphoesterase superfamily. Mazumder R, et al. Nucleic Acids Res, 2002 Dec 1. PMID 12466548, Free PMC Article
  5. spenito is required for sex determination in Drosophila melanogaster. Yan D, et al. Proc Natl Acad Sci U S A, 2015 Sep 15. PMID 26324914, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA alkylation repair IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG12129-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    10033304..10034698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136701.3 → NP_610545.1  uncharacterized protein Dmel_CG12129 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610545.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JW66
    Related
    FBpp0087483
    Conserved Domains (3) summary
    PLN00108
    Location:182 → 352
    PLN00108; unknown protein; Provisional
    cd02394
    Location:77 → 138
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:151 → 352
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JW66 Q7JW66

Gene LinkOut

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