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Ptprq protein tyrosine phosphatase, receptor type, Q [ Rattus norvegicus (Norway rat) ]

Gene ID: 360417, updated on 27-Nov-2024

Summary

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Official Symbol
Ptprqprovided by RGD
Official Full Name
protein tyrosine phosphatase, receptor type, Qprovided by RGD
Primary source
RGD:620779
See related
EnsemblRapid:ENSRNOG00000056915 AllianceGenome:RGD:620779
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
rPTP-GMC1
Summary
Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in detection of mechanical stimulus involved in sensory perception of sound and regulation of fat cell differentiation. Predicted to act upstream of or within hematopoietic progenitor cell differentiation; neuromuscular process controlling balance; and vestibular receptor cell morphogenesis. Predicted to be located in apical plasma membrane and stereocilium base. Predicted to be part of receptor complex. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 73 and autosomal recessive nonsyndromic deafness 84A. Orthologous to human PTPRQ (protein tyrosine phosphatase receptor type Q). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 9.9), Kidney (RPKM 2.7) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Ptprq in Genome Data Viewer
Location:
7q21
Exon count:
45
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (44720916..44903291, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (42834455..43016807, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (49763657..50034932, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093580 Neighboring gene myogenic factor 5 Neighboring gene myogenic factor 6 Neighboring gene otogelin-like Neighboring gene protein phosphatase 1, regulatory subunit 12A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Involvement of PTP-RQ in differentiation during adipogenesis of human mesenchymal stem cells. Jung H, et al. Biochem Biophys Res Commun, 2009 May 29. PMID 19351528
  2. PTPRQ is a novel phosphatidylinositol phosphatase that can be expressed as a cytoplasmic protein or as a subcellularly localized receptor-like protein. Seifert RA, et al. Exp Cell Res, 2003 Jul 15. PMID 12837292
  3. Hair bundle defects and loss of function in the vestibular end organs of mice lacking the receptor-like inositol lipid phosphatase PTPRQ. Goodyear RJ, et al. J Neurosci, 2012 Feb 22. PMID 22357859, Free PMC Article
  4. A receptor-like inositol lipid phosphatase is required for the maturation of developing cochlear hair bundles. Goodyear RJ, et al. J Neurosci, 2003 Oct 8. PMID 14534255, Free PMC Article
  5. Protein tyrosine phosphatase RQ is a phosphatidylinositol phosphatase that can regulate cell survival and proliferation. Oganesian A, et al. Proc Natl Acad Sci U S A, 2003 Jun 24. PMID 12802008, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PTPRQ represents a subtype of the PTPases whose biological activities result from its PIPase activity rather than its PTPase activity
    Title: Protein tyrosine phosphatase RQ is a phosphatidylinositol phosphatase that can regulate cell survival and proliferation.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables histone H2AXY142 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity, metal-dependent IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in detection of mechanical stimulus involved in sensory perception of sound IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in detection of mechanical stimulus involved in sensory perception of sound IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of sound ISO
Inferred from Sequence Orthology
more info
  
involved_in hematopoietic progenitor cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within inner ear morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in neuromuscular process controlling balance IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neuromuscular process controlling balance ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in vestibular receptor cell morphogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within vestibular receptor cell morphogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in basal plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in stereocilium base IEA
Inferred from Electronic Annotation
more info
  
located_in stereocilium base ISO
Inferred from Sequence Orthology
more info
  
located_in stereocilium base ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in stereocilium bundle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phosphatidylinositol phosphatase PTPRQ
Names
PTP-RQ
R-PTP-Q
glomerular mesangial cell receptor protein-tyrosine phosphatase
phosphotidylinositol phosphatase PTPRQ
protein-tyrosine phosphatase receptor-type expressed by glomerular mesangial cells protein 1
receptor-type tyrosine-protein phosphatase Q
NP_075214.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022925.2 → NP_075214.2  phosphatidylinositol phosphatase PTPRQ precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    O88488
    UniProtKB/TrEMBL
    A0A0G2JUZ7, A6IGD1
    Related
    ENSRNOP00000069293.2, ENSRNOT00000081885.3
    Conserved Domains (5) summary
    cd00063
    Location:58 → 152
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl06408
    Location:1760 → 1929
    UP_III_II; Uroplakin IIIb, IIIa and II
    cd14616
    Location:2034 → 2257
    R-PTPc-Q; catalytic domain of receptor-type tyrosine-protein phosphatase Q
    pfam00041
    Location:669 → 748
    fn3; Fibronectin type III domain
    cl21522
    Location:400 → 442
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    44720916..44903291 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_198323.1: Suppressed sequence

    Description
    NM_198323.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88488.1 GenPept UniProtKB/Swiss-Prot:O88488

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