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Ptprk protein tyrosine phosphatase, receptor type, K [ Rattus norvegicus (Norway rat) ]

Gene ID: 360302, updated on 4-Jan-2025

Summary

Official Symbol
Ptprkprovided by RGD
Official Full Name
protein tyrosine phosphatase, receptor type, Kprovided by RGD
Primary source
RGD:619706
See related
EnsemblRapid:ENSRNOG00000047605 AllianceGenome:RGD:619706
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rptpk
Summary
Predicted to enable several functions, including beta-catenin binding activity; gamma-catenin binding activity; and protein tyrosine phosphatase activity. Involved in T cell differentiation; cell adhesion; and neuron projection development. Predicted to be located in several cellular components, including leading edge membrane; neuronal cell body; and photoreceptor outer segment. Orthologous to human PTPRK (protein tyrosine phosphatase receptor type K). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 161.2), Lung (RPKM 125.4) and 9 other tissues See more
Orthologs
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Genomic context

See Ptprk in Genome Data Viewer
Location:
1p12
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (18557091..19056297, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (16738896..17236687, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (17445052..18058266, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene thymocyte selection associated Neighboring gene antagonist of mitotic exit network 1, pseudogene 1 Neighboring gene autophagy related 4B, cysteine peptidase, pseudogene 1 Neighboring gene uncharacterized LOC120098804 Neighboring gene uncharacterized LOC120098806 Neighboring gene uncharacterized LOC134484965 Neighboring gene uncharacterized LOC120098805 Neighboring gene uncharacterized LOC134484966 Neighboring gene ribosomal protein lateral stalk subunit P0, pseudogene 4 Neighboring gene RuvB-like AAA ATPase 1, pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables gamma-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in T cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to UV ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
involved_in focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of keratinocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in leading edge membrane ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in photoreceptor outer segment ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
receptor-type tyrosine-protein phosphatase kappa
Names
protein tyrosine phosphatase, receptor type, K, extracellular region
receptor-like protein tyrosine phosphatase kappa extracellular region (RPTPK)
NP_001025073.2
XP_063121937.1
XP_063121938.1
XP_063121941.1
XP_063121942.1
XP_063121945.1
XP_063121947.1
XP_063121950.1
XP_063121954.1
XP_063121957.1
XP_063121959.1
XP_063121968.1
XP_063121975.1
XP_063121976.1
XP_063121977.1
XP_063121983.1
XP_063121989.1
XP_063121997.1
XP_063122006.1
XP_063122009.1
XP_063122013.1
XP_063122014.1
XP_063122015.1
XP_063122018.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029902.2NP_001025073.2  receptor-type tyrosine-protein phosphatase kappa precursor

    See identical proteins and their annotated locations for NP_001025073.2

    Status: PROVISIONAL

    Source sequence(s)
    AB297790
    UniProtKB/TrEMBL
    A5I9F0, F1LPL4
    Conserved Domains (9) summary
    cd06263
    Location:35191
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:31191
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:8861140
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:201287
    IG_like; Immunoglobulin like
    cd00047
    Location:9131140
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:487588
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:293371
    fn3; Fibronectin type III domain
    pfam00102
    Location:12001434
    Y_phosphatase; Protein-tyrosine phosphatase
    cl11960
    Location:203283
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    18557091..19056297 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265927.1XP_063121997.1  receptor-type tyrosine-protein phosphatase kappa isoform X17

  2. XM_063265913.1XP_063121983.1  receptor-type tyrosine-protein phosphatase kappa isoform X15

  3. XM_063265905.1XP_063121975.1  receptor-type tyrosine-protein phosphatase kappa isoform X12

  4. XM_063265948.1XP_063122018.1  receptor-type tyrosine-protein phosphatase kappa isoform X23

  5. XM_063265880.1XP_063121950.1  receptor-type tyrosine-protein phosphatase kappa isoform X7

  6. XM_063265868.1XP_063121938.1  receptor-type tyrosine-protein phosphatase kappa isoform X2

  7. XM_063265919.1XP_063121989.1  receptor-type tyrosine-protein phosphatase kappa isoform X16

  8. XM_063265907.1XP_063121977.1  receptor-type tyrosine-protein phosphatase kappa isoform X14

  9. XM_063265906.1XP_063121976.1  receptor-type tyrosine-protein phosphatase kappa isoform X13

  10. XM_063265898.1XP_063121968.1  receptor-type tyrosine-protein phosphatase kappa isoform X11

    Related
    ENSRNOP00000105620.1, ENSRNOT00000150254.1
  11. XM_063265887.1XP_063121957.1  receptor-type tyrosine-protein phosphatase kappa isoform X9

  12. XM_063265945.1XP_063122015.1  receptor-type tyrosine-protein phosphatase kappa isoform X22

    Related
    ENSRNOP00000108431.1, ENSRNOT00000156515.1
  13. XM_063265877.1XP_063121947.1  receptor-type tyrosine-protein phosphatase kappa isoform X6

    Related
    ENSRNOP00000100835.1, ENSRNOT00000121655.1
  14. XM_063265889.1XP_063121959.1  receptor-type tyrosine-protein phosphatase kappa isoform X10

    Related
    ENSRNOP00000107475.1, ENSRNOT00000121569.1
  15. XM_063265884.1XP_063121954.1  receptor-type tyrosine-protein phosphatase kappa isoform X8

  16. XM_063265875.1XP_063121945.1  receptor-type tyrosine-protein phosphatase kappa isoform X5

  17. XM_063265871.1XP_063121941.1  receptor-type tyrosine-protein phosphatase kappa isoform X3

    Related
    ENSRNOP00000104699.1, ENSRNOT00000132092.1
  18. XM_063265872.1XP_063121942.1  receptor-type tyrosine-protein phosphatase kappa isoform X4

  19. XM_063265867.1XP_063121937.1  receptor-type tyrosine-protein phosphatase kappa isoform X1

    Related
    ENSRNOP00000099423.1, ENSRNOT00000151000.1
  20. XM_063265943.1XP_063122013.1  receptor-type tyrosine-protein phosphatase kappa isoform X20

    UniProtKB/TrEMBL
    A6JPF0
  21. XM_063265939.1XP_063122009.1  receptor-type tyrosine-protein phosphatase kappa isoform X19

    UniProtKB/TrEMBL
    A6JPF0
  22. XM_063265936.1XP_063122006.1  receptor-type tyrosine-protein phosphatase kappa isoform X18

    UniProtKB/TrEMBL
    A6JPF0
  23. XM_063265944.1XP_063122014.1  receptor-type tyrosine-protein phosphatase kappa isoform X21