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Nek6 NIMA-related kinase 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360161, updated on 4-Jan-2025

Summary

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Official Symbol
Nek6provided by RGD
Official Full Name
NIMA-related kinase 6provided by RGD
Primary source
RGD:727779
See related
EnsemblRapid:ENSRNOG00000010897 AllianceGenome:RGD:727779
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables protein serine/threonine kinase activity. Predicted to be involved in several processes, including positive regulation of canonical NF-kappaB signal transduction; protein phosphorylation; and regulation of mitotic metaphase/anaphase transition. Predicted to be located in centriolar satellite; cytosol; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Orthologous to human NEK6 (NIMA related kinase 6). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Lung (RPKM 69.4), Liver (RPKM 68.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nek6 in Genome Data Viewer
Location:
3q12
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (42693994..42766026)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (22284269..22356302)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (22811927..22888598)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene LIM homeobox 2 Neighboring gene double PHD fingers 3 like 1 Neighboring gene uncharacterized LOC120101538 Neighboring gene proteasome 20S subunit beta 7 Neighboring gene ALG11, alpha-1,2-mannosyltransferase, pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The serine/threonine kinase Nek6 is required for cell cycle progression through mitosis. Yin MJ, et al. J Biol Chem, 2003 Dec 26. PMID 14563848
  2. Identification and characterization of Nek6 protein kinase, a potential human homolog of NIMA histone H3 kinase. Hashimoto Y, et al. Biochem Biophys Res Commun, 2002 May 3. PMID 12054534
  3. Identification of the NIMA family kinases NEK6/7 as regulators of the p70 ribosomal S6 kinase. Belham C, et al. Curr Biol, 2001 Aug 7. PMID 11516946
  4. A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases. Belham C, et al. J Biol Chem, 2003 Sep 12. PMID 12840024
  5. The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation. Rapley J, et al. J Cell Sci, 2008 Dec 1. PMID 19001501, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables DNA-binding transcription factor binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinesin binding IEA
Inferred from Electronic Annotation
more info
  
enables kinesin binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription corepressor binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in chromosome segregation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of mitotic metaphase/anaphase transition IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mitotic metaphase/anaphase transition ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitotic metaphase/anaphase transition ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in centriolar satellite IEA
Inferred from Electronic Annotation
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase Nek6
Names
NIMA (never in mitosis gene a)-related expressed kinase 6
never in mitosis A-related kinase 6
nimA-related protein kinase 6
NP_001264161.1
NP_891998.1
XP_006234162.1
XP_017447355.1
XP_038961262.1
XP_038961263.1
XP_038961264.1
XP_038961265.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277232.1 → NP_001264161.1  serine/threonine-protein kinase Nek6

    See identical proteins and their annotated locations for NP_001264161.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC160820, JAXUCZ010000003
    UniProtKB/Swiss-Prot
    P59895
    UniProtKB/TrEMBL
    A0A8L2R1R0, B1H218
    Conserved Domains (1) summary
    cd08224
    Location:44 → 305
    STKc_Nek6_7; Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related kinase 6 and 7

  2. NM_182953.2 → NP_891998.1  serine/threonine-protein kinase Nek6

    See identical proteins and their annotated locations for NP_891998.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC160820, JAXUCZ010000003
    UniProtKB/Swiss-Prot
    P59895
    UniProtKB/TrEMBL
    A0A8L2R1R0, B1H218
    Related
    ENSRNOP00000083098.1, ENSRNOT00000116855.2
    Conserved Domains (1) summary
    cd08224
    Location:44 → 305
    STKc_Nek6_7; Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related kinase 6 and 7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    42693994..42766026
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234100.3 → XP_006234162.1  serine/threonine-protein kinase Nek6 isoform X1

    See identical proteins and their annotated locations for XP_006234162.1

    UniProtKB/Swiss-Prot
    P59895
    UniProtKB/TrEMBL
    A0A8L2R1R0, B1H218
    Conserved Domains (1) summary
    cd08224
    Location:44 → 305
    STKc_Nek6_7; Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related kinase 6 and 7

  2. XM_039105336.2 → XP_038961264.1  serine/threonine-protein kinase Nek6 isoform X1

    UniProtKB/Swiss-Prot
    P59895
    UniProtKB/TrEMBL
    A0A8L2R1R0, B1H218
    Conserved Domains (1) summary
    cd08224
    Location:44 → 305
    STKc_Nek6_7; Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related kinase 6 and 7

  3. XM_039105335.2 → XP_038961263.1  serine/threonine-protein kinase Nek6 isoform X1

    UniProtKB/Swiss-Prot
    P59895
    UniProtKB/TrEMBL
    A0A8L2R1R0, B1H218
    Conserved Domains (1) summary
    cd08224
    Location:44 → 305
    STKc_Nek6_7; Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related kinase 6 and 7

  4. XM_017591866.3 → XP_017447355.1  serine/threonine-protein kinase Nek6 isoform X1

    UniProtKB/Swiss-Prot
    P59895
    UniProtKB/TrEMBL
    A0A8L2R1R0, B1H218
    Conserved Domains (1) summary
    cd08224
    Location:44 → 305
    STKc_Nek6_7; Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related kinase 6 and 7

  5. XM_039105337.2 → XP_038961265.1  serine/threonine-protein kinase Nek6 isoform X1

    UniProtKB/Swiss-Prot
    P59895
    UniProtKB/TrEMBL
    A0A8L2R1R0, B1H218
    Related
    ENSRNOP00000069207.2, ENSRNOT00000086147.3
    Conserved Domains (1) summary
    cd08224
    Location:44 → 305
    STKc_Nek6_7; Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related kinase 6 and 7

  6. XM_039105334.2 → XP_038961262.1  serine/threonine-protein kinase Nek6 isoform X1

    UniProtKB/Swiss-Prot
    P59895
    UniProtKB/TrEMBL
    A0A8L2R1R0, B1H218
    Conserved Domains (1) summary
    cd08224
    Location:44 → 305
    STKc_Nek6_7; Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related kinase 6 and 7
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P59895.1 GenPept UniProtKB/Swiss-Prot:P59895

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