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CG12926 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35996, updated on 9-Dec-2024

Summary

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Official Symbol
CG12926provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0033437
Locus tag
Dmel_CG12926
See related
AllianceGenome:FB:FBgn0033437
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG12926
Summary
Predicted to enable lipid transfer activity and phosphatidylinositol bisphosphate binding activity. Predicted to be involved in intermembrane lipid transfer. Predicted to be located in late endosome. Is expressed in adult head; anterior endoderm anlage; anterior midgut primordium; embryonic/larval midgut; and posterior midgut primordium. Orthologous to human TTPAL (alpha tocopherol transfer protein like). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG12926 in Genome Data Viewer
Location:
45F6-45F6; 2-61 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9608128..9610290, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5495633..5497795, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44285 Neighboring gene antisense RNA:CR44069 Neighboring gene Glutathione S transferase T1 Neighboring gene Glutathione S transferase T2 Neighboring gene Matrix metalloproteinase 2 Neighboring gene mir-307b stem loop Neighboring gene mir-307a stem loop

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. dRTEL1 is essential for the maintenance of Drosophila male germline stem cells. Yang Y, et al. PLoS Genet, 2021 Oct. PMID 34644293, Free PMC Article
  2. Brain-specific lipoprotein receptors interact with astrocyte derived apolipoprotein and mediate neuron-glia lipid shuttling. Yin J, et al. Nat Commun, 2021 Apr 23. PMID 33893307, Free PMC Article
  3. A deletion-generator compound element allows deletion saturation analysis for genomewide phenotypic annotation. Huet F, et al. Proc Natl Acad Sci U S A, 2002 Jul 23. PMID 12096187, Free PMC Article
  4. Loss of PAFAH1B2 reduces amyloid-β generation by promoting the degradation of amyloid precursor protein C-terminal fragments. Page RM, et al. J Neurosci, 2012 Dec 12. PMID 23238734, Free PMC Article
  5. A neurogenetic mechanism of experience-dependent suppression of aggression. Ishii K, et al. Sci Adv, 2022 Sep 9. PMID 36070378, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables lipid transfer activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylinositol bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol bisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in intermembrane lipid transfer ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in late endosome ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG12926-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9608128..9610290 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136666.4 → NP_610510.2  uncharacterized protein Dmel_CG12926 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610510.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7X8, Q8SXZ7
    Related
    FBpp0087586
    Conserved Domains (2) summary
    smart01100
    Location:32 → 77
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    cd00170
    Location:117 → 254
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z7X8 A1Z7X8
Q8SXZ7 Q8SXZ7

Gene LinkOut

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