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Urod Uroporphyrinogen decarboxylase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35986, updated on 9-Dec-2024

Summary

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Official Symbol
Urodprovided by FlyBase
Official Full Name
Uroporphyrinogen decarboxylaseprovided by FlyBase
Primary source
FLYBASE:FBgn0033428
Locus tag
Dmel_CG1818
See related
AllianceGenome:FB:FBgn0033428
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1818; Dmel\CG1818; Updo
Summary
Predicted to enable uroporphyrinogen decarboxylase activity. Predicted to be involved in heme biosynthetic process. Predicted to be active in cytosol. Is expressed in several structures, including adult head; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut; and embryonic/larval midgut primordium. Used to study porphyria. Human ortholog(s) of this gene implicated in porphyria cutanea tarda. Orthologous to human UROD (uroporphyrinogen decarboxylase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Urod in Genome Data Viewer
Location:
45F5-45F5; 2-61 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9584643..9586126)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5472148..5473631)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Not1 Neighboring gene long non-coding RNA:CR46257 Neighboring gene 5' nucleotidase C Neighboring gene SET and MYND domain containing, class 4, member 1 Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein L31 Neighboring gene closca Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Glycogen branching enzyme controls cellular iron homeostasis via Iron Regulatory Protein 1 and mitoNEET. Huynh N, et al. Nat Commun, 2019 Nov 29. PMID 31784520, Free PMC Article
  2. Identification and characterization of a heme exporter from the MRP family in Drosophila melanogaster. Wang Z, et al. BMC Biol, 2022 Jun 2. PMID 35655259, Free PMC Article
  3. Comparative transcriptomics across 14 Drosophila species reveals signatures of longevity. Ma S, et al. Aging Cell, 2018 Aug. PMID 29671950, Free PMC Article
  4. Evolution of amino-acid sequences and codon usage on the Drosophila miranda neo-sex chromosomes. Bartolomé C, et al. Genetics, 2006 Dec. PMID 17028318, Free PMC Article
  5. Rates and patterns of chromosomal evolution in Drosophila pseudoobscura and D. miranda. Bartolomé C, et al. Genetics, 2006 Jun. PMID 16547107, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables uroporphyrinogen decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables uroporphyrinogen decarboxylase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in heme biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in porphyrin-containing compound biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uroporphyrinogen decarboxylase
Names
CG1818-PA
Urod-PA
updo
NP_610501.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9584643..9586126
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136657.3 → NP_610501.1  uroporphyrinogen decarboxylase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610501.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V595
    UniProtKB/TrEMBL
    B5RJ76, Q8MRV9
    Related
    FBpp0087607
    Conserved Domains (1) summary
    TIGR01464
    Location:14 → 354
    hemE; uroporphyrinogen decarboxylase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MRV9 Q8MRV9
Q9V595.1 Q9V595

Gene LinkOut

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