Wnt2 Wnt oncogene analog 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Wnt2provided by FlyBase
Official Full Name: Wnt oncogene analog 2provided by FlyBase
Primary source: FLYBASE:FBgn0004360
Locus tag: Dmel_CG1916
See related: AllianceGenome:FB:FBgn0004360
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1916; D-wnt-2; Dm DWnt2; Dm-2; Dmel\CG1916; Dwnt-2; DWnt-2; dWnt2; Dwnt2; DWnt2; Wnt; wnt-2; Wnt-2; wnt2
Summary: Enables frizzled binding activity. Involved in several processes, including axon extension; canonical Wnt signaling pathway; and germ-line stem-cell niche homeostasis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including labrum; male genital disc primordium; proctodeum; segment; and seminal vesicle. Human ortholog(s) of this gene implicated in Fuhrmann syndrome; Mullerian aplasia and hyperandrogenism; and Schinzel type phocomelia. Orthologous to several human genes including WNT7B (Wnt family member 7B). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 45E1-45E1; 2-60 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (9494166..9503188)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (5381671..5390693)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Wnt2 overexpression protects against PINK1 mutantinduced mitochondrial dysfunction and oxidative stress.
Title: Wnt2 overexpression protects against PINK1 mutant‑induced mitochondrial dysfunction and oxidative stress.
We discovered an otk paralog (otk2, CG8964), which is co-expressed with otk throughout embryonic and larval development. Otk and Otk2 bind to each other and form complexes with Frizzled, Frizzled2 and Wnt2, pointing to a function as Wnt co-receptors.
Title: The PTK7-related transmembrane proteins off-track and off-track 2 are co-receptors for Drosophila Wnt2 required for male fertility.
Mutations in Wnt2 alter presynaptic motor neuron morphology and presynaptic protein localization at the neuromuscular junction.
Title: Mutations in Wnt2 alter presynaptic motor neuron morphology and presynaptic protein localization at the Drosophila neuromuscular junction.
It activates beta-catenin-independent pathway, such as planar cell polarity pathway, calcium signaling. (review)
Title: [Activation of the beta-catenin-independent pathway by Wnt and the diseases due to its abnormality].
Data show that Drosophila Naked cuticle (Nkd) engages the nuclear import adaptor Importin-alpha3 to antagonize Wnt/beta-catenin signaling.
Title: Drosophila Naked cuticle (Nkd) engages the nuclear import adaptor Importin-alpha3 to antagonize Wnt/beta-catenin signaling.
DWnt-2 promotes correct patterning of direct flight muscles through a mechanism that is independent of the attachment site differentiation initiated by stripe.
Title: Direct flight muscles in Drosophila develop from cells with characteristics of founders and depend on DWnt-2 for their correct patterning.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
involved_in germ-line stem-cell niche homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in open tracheal system development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of JNK cascade	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Wnt oncogene analog 2

Names: CG1916-PA; CG1916-PB; Wnt2-PA; Wnt2-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

9494166..9503188

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057462.5 → NP_476810.1 Wnt oncogene analog 2, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476810.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P28465, Q86PC8, Q9V584

UniProtKB/TrEMBL

I0E2I5

Related

FBpp0087596

Conserved Domains (1) summary

pfam00110
Location:36 → 352

wnt; wnt family
NM_001299322.1 → NP_001286251.1 Wnt oncogene analog 2, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286251.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LFY4

Conserved Domains (1) summary

cd19339
Location:2 → 325

Wnt_Wnt7; Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins