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Wnt2 Wnt oncogene analog 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35975, updated on 9-Dec-2024

Summary

Official Symbol
Wnt2provided by FlyBase
Official Full Name
Wnt oncogene analog 2provided by FlyBase
Primary source
FLYBASE:FBgn0004360
Locus tag
Dmel_CG1916
See related
AllianceGenome:FB:FBgn0004360
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1916; D-wnt-2; Dm DWnt2; Dm-2; Dmel\CG1916; Dwnt-2; DWnt-2; dWnt2; Dwnt2; DWnt2; Wnt; wnt-2; Wnt-2; wnt2
Summary
Enables frizzled binding activity. Involved in several processes, including axon extension; canonical Wnt signaling pathway; and germ-line stem-cell niche homeostasis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including labrum; male genital disc primordium; proctodeum; segment; and seminal vesicle. Human ortholog(s) of this gene implicated in Fuhrmann syndrome; Mullerian aplasia and hyperandrogenism; and Schinzel type phocomelia. Orthologous to several human genes including WNT7B (Wnt family member 7B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See Wnt2 in Genome Data Viewer
Location:
45E1-45E1; 2-60 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9494166..9503188)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5381671..5390693)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Calmodulin-binding transcription activator Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene bruchpilot Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables frizzled binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables signaling receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in axon extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in germ-line stem-cell niche homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in muscle organ development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in open tracheal system development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
Wnt oncogene analog 2
Names
CG1916-PA
CG1916-PB
Wnt2-PA
Wnt2-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9494166..9503188
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057462.5NP_476810.1  Wnt oncogene analog 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476810.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P28465, Q86PC8, Q9V584
    UniProtKB/TrEMBL
    I0E2I5
    Related
    FBpp0087596
    Conserved Domains (1) summary
    pfam00110
    Location:36352
    wnt; wnt family
  2. NM_001299322.1NP_001286251.1  Wnt oncogene analog 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286251.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LFY4
    Conserved Domains (1) summary
    cd19339
    Location:2325
    Wnt_Wnt7; Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins