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Rnasel ribonuclease L [ Rattus norvegicus (Norway rat) ]

Gene ID: 359726, updated on 14-Nov-2024

Summary

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Official Symbol
Rnaselprovided by RGD
Official Full Name
ribonuclease Lprovided by RGD
Primary source
RGD:727933
See related
EnsemblRapid:ENSRNOG00000027017 AllianceGenome:RGD:727933
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables RNA nuclease activity and rRNA binding activity. Involved in rRNA processing. Located in nuclear matrix. Human ortholog(s) of this gene implicated in Lynch syndrome and prostate cancer. Orthologous to human RNASEL (ribonuclease L). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 67.5), Thymus (RPKM 55.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rnasel in Genome Data Viewer
Location:
13q21
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (68446641..68460804)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (65894990..65910354)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (71188712..71202636)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene regulator of G-protein signaling 8 Neighboring gene regulator of G-protein signaling 16 Neighboring gene regulator of G-protein signaling like 1 Neighboring gene heterogeneous nuclear ribonucleoprotein A3-like Neighboring gene regulator of G-protein signaling like 2 homolog (mouse) Neighboring gene glutamate-ammonia ligase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Evidence for age-dependent impairment of antiviral 2',5'-oligoadenylate synthetase/ribonuclease L-system in tissues of rat. Pfeifer K, et al. Mech Ageing Dev, 1993 Feb. PMID 8469023
  2. Mutations in ribonuclease L gene do not occur at a greater frequency in patients with familial prostate cancer compared with patients with sporadic prostate cancer. Downing SR, et al. Clin Prostate Cancer, 2003 Dec. PMID 15040862
  3. Lineage A Betacoronavirus NS2 Proteins and the Homologous Torovirus Berne pp1a Carboxy-Terminal Domain Are Phosphodiesterases That Antagonize Activation of RNase L. Goldstein SA, et al. J Virol, 2017 Mar 1. PMID 28003490, Free PMC Article
  4. Structure of human RNase L reveals the basis for regulated RNA decay in the IFN response. Han Y, et al. Science, 2014 Mar 14. PMID 24578532, Free PMC Article
  5. Role of ribonuclease L in viral pathogen-associated molecular pattern/influenza virus and cigarette smoke-induced inflammation and remodeling. Zhou Y, et al. J Immunol, 2013 Sep 1. PMID 23913960, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA nuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA nuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA nuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables rRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribonucleoprotein complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of viral genome replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of D-glucose import ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in rRNA processing IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of mRNA stability ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nuclear matrix IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
2-5A-dependent ribonuclease
Names
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
ribonuclease L (2, 5-oligoisoadenylate synthetase-dependent)
NP_872614.1
XP_006250061.1
XP_006250066.1
XP_038946795.1
XP_038946796.1
XP_038946797.1
XP_038946798.1
XP_038946799.1
XP_038946800.1
XP_038946801.1
XP_038946802.1
XP_063128491.1
XP_063128493.1
XP_063128494.1
XP_063128495.1
XP_063128496.1
XP_063128497.1
XP_063128498.1
XP_063128499.1
XP_063128500.1
XP_063128501.1
XP_063128502.1
XP_063128503.1
XP_063128504.1
XP_063128505.1
XP_063128506.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_182673.2 → NP_872614.1  2-5A-dependent ribonuclease

    See identical proteins and their annotated locations for NP_872614.1

    Status: PROVISIONAL

    Source sequence(s)
    AY262823
    UniProtKB/TrEMBL
    Q80WM6
    Conserved Domains (7) summary
    cd10423
    Location:593 → 710
    RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
    cd00204
    Location:59 → 188
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00069
    Location:374 → 589
    Pkinase; Protein kinase domain
    pfam12796
    Location:63 → 153
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:28 → 79
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:59 → 89
    ANK; ANK repeat [structural motif]
    cl21453
    Location:366 → 590
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    68446641..68460804
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090872.2 → XP_038946800.1  2-5A-dependent ribonuclease isoform X1

    Conserved Domains (7) summary
    PTZ00322
    Location:259 → 369
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    PHA02875
    Location:29 → 188
    PHA02875; ankyrin repeat protein; Provisional
    cd10423
    Location:599 → 715
    RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
    sd00045
    Location:59 → 89
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:170 → 216
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:224 → 302
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:379 → 590
    PKc_like; Protein Kinases, catalytic domain

  2. XM_006250004.5 → XP_006250066.1  2-5A-dependent ribonuclease isoform X3

    Conserved Domains (6) summary
    cd00204
    Location:59 → 188
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00069
    Location:374 → 589
    Pkinase; Protein kinase domain
    pfam12796
    Location:63 → 153
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:28 → 79
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:59 → 89
    ANK; ANK repeat [structural motif]
    cl21453
    Location:379 → 590
    PKc_like; Protein Kinases, catalytic domain

  3. XM_039090873.2 → XP_038946801.1  2-5A-dependent ribonuclease isoform X1

    Conserved Domains (7) summary
    PTZ00322
    Location:259 → 369
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    PHA02875
    Location:29 → 188
    PHA02875; ankyrin repeat protein; Provisional
    cd10423
    Location:599 → 715
    RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
    sd00045
    Location:59 → 89
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:170 → 216
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:224 → 302
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:379 → 590
    PKc_like; Protein Kinases, catalytic domain

  4. XM_039090874.2 → XP_038946802.1  2-5A-dependent ribonuclease isoform X1

    Conserved Domains (7) summary
    PTZ00322
    Location:259 → 369
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    PHA02875
    Location:29 → 188
    PHA02875; ankyrin repeat protein; Provisional
    cd10423
    Location:599 → 715
    RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
    sd00045
    Location:59 → 89
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:170 → 216
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:224 → 302
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:379 → 590
    PKc_like; Protein Kinases, catalytic domain

  5. XM_063272421.1 → XP_063128491.1  2-5A-dependent ribonuclease isoform X1

  6. XM_039090867.2 → XP_038946795.1  2-5A-dependent ribonuclease isoform X1

    Conserved Domains (7) summary
    PTZ00322
    Location:259 → 369
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    PHA02875
    Location:29 → 188
    PHA02875; ankyrin repeat protein; Provisional
    cd10423
    Location:599 → 715
    RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
    sd00045
    Location:59 → 89
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:170 → 216
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:224 → 302
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:379 → 590
    PKc_like; Protein Kinases, catalytic domain

  7. XM_063272423.1 → XP_063128493.1  2-5A-dependent ribonuclease isoform X1

  8. XM_039090870.2 → XP_038946798.1  2-5A-dependent ribonuclease isoform X1

    Conserved Domains (7) summary
    PTZ00322
    Location:259 → 369
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    PHA02875
    Location:29 → 188
    PHA02875; ankyrin repeat protein; Provisional
    cd10423
    Location:599 → 715
    RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
    sd00045
    Location:59 → 89
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:170 → 216
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:224 → 302
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:379 → 590
    PKc_like; Protein Kinases, catalytic domain

  9. XM_063272436.1 → XP_063128506.1  2-5A-dependent ribonuclease isoform X2

    UniProtKB/TrEMBL
    A6ICV9, G3V915

  10. XM_063272434.1 → XP_063128504.1  2-5A-dependent ribonuclease isoform X2

    UniProtKB/TrEMBL
    A6ICV9, G3V915

  11. XM_063272435.1 → XP_063128505.1  2-5A-dependent ribonuclease isoform X2

    UniProtKB/TrEMBL
    A6ICV9, G3V915

  12. XM_063272426.1 → XP_063128496.1  2-5A-dependent ribonuclease isoform X2

    UniProtKB/TrEMBL
    A6ICV9, G3V915

  13. XM_006249999.5 → XP_006250061.1  2-5A-dependent ribonuclease isoform X2

    See identical proteins and their annotated locations for XP_006250061.1

    UniProtKB/TrEMBL
    A6ICV9, G3V915
    Related
    ENSRNOP00000032975.3, ENSRNOT00000032157.6
    Conserved Domains (7) summary
    PTZ00322
    Location:259 → 369
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    PHA02875
    Location:29 → 188
    PHA02875; ankyrin repeat protein; Provisional
    cd10423
    Location:593 → 710
    RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
    sd00045
    Location:59 → 89
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:170 → 216
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:224 → 302
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:379 → 590
    PKc_like; Protein Kinases, catalytic domain

  14. XM_063272428.1 → XP_063128498.1  2-5A-dependent ribonuclease isoform X2

    UniProtKB/TrEMBL
    A6ICV9, G3V915

  15. XM_063272429.1 → XP_063128499.1  2-5A-dependent ribonuclease isoform X2

    UniProtKB/TrEMBL
    A6ICV9, G3V915

  16. XM_063272431.1 → XP_063128501.1  2-5A-dependent ribonuclease isoform X2

    UniProtKB/TrEMBL
    A6ICV9, G3V915

  17. XM_063272425.1 → XP_063128495.1  2-5A-dependent ribonuclease isoform X1

  18. XM_039090868.2 → XP_038946796.1  2-5A-dependent ribonuclease isoform X1

    Conserved Domains (7) summary
    PTZ00322
    Location:259 → 369
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    PHA02875
    Location:29 → 188
    PHA02875; ankyrin repeat protein; Provisional
    cd10423
    Location:599 → 715
    RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
    sd00045
    Location:59 → 89
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:170 → 216
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:224 → 302
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:379 → 590
    PKc_like; Protein Kinases, catalytic domain

  19. XM_063272424.1 → XP_063128494.1  2-5A-dependent ribonuclease isoform X1

  20. XM_063272427.1 → XP_063128497.1  2-5A-dependent ribonuclease isoform X2

    UniProtKB/TrEMBL
    A6ICV9, G3V915

  21. XM_063272432.1 → XP_063128502.1  2-5A-dependent ribonuclease isoform X2

    UniProtKB/TrEMBL
    A6ICV9, G3V915

  22. XM_039090871.1 → XP_038946799.1  2-5A-dependent ribonuclease isoform X1

    Conserved Domains (7) summary
    PTZ00322
    Location:259 → 369
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    PHA02875
    Location:29 → 188
    PHA02875; ankyrin repeat protein; Provisional
    cd10423
    Location:599 → 715
    RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
    sd00045
    Location:59 → 89
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:170 → 216
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:224 → 302
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:379 → 590
    PKc_like; Protein Kinases, catalytic domain

  23. XM_063272433.1 → XP_063128503.1  2-5A-dependent ribonuclease isoform X2

    UniProtKB/TrEMBL
    A6ICV9, G3V915

  24. XM_039090869.2 → XP_038946797.1  2-5A-dependent ribonuclease isoform X1

    Conserved Domains (7) summary
    PTZ00322
    Location:259 → 369
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    PHA02875
    Location:29 → 188
    PHA02875; ankyrin repeat protein; Provisional
    cd10423
    Location:599 → 715
    RNase_RNase-L; RNase domain (also known as the kinase extension nuclease domain) of RNase L
    sd00045
    Location:59 → 89
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:170 → 216
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:224 → 302
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:379 → 590
    PKc_like; Protein Kinases, catalytic domain

  25. XM_063272430.1 → XP_063128500.1  2-5A-dependent ribonuclease isoform X2

    UniProtKB/TrEMBL
    A6ICV9, G3V915
Nucleotide Protein Strain
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