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prel preli-like [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35969, updated on 4-Jan-2025

Summary

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Official Symbol
prelprovided by FlyBase
Official Full Name
preli-likeprovided by FlyBase
Primary source
FLYBASE:FBgn0033413
Locus tag
Dmel_CG8806
See related
AllianceGenome:FB:FBgn0033413
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:LD36516; CG8806; Dmel\CG8806
Summary
Predicted to enable phosphatidic acid transfer activity. Involved in dendrite morphogenesis and mitochondrion organization. Located in mitochondrial crista. Is expressed in adult head. Orthologous to human PRELID1 (PRELI domain containing 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See prel in Genome Data Viewer
Location:
45D5-45D5; 2-60 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9424087..9426107)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5311592..5313612)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene wunen-2 Neighboring gene uncharacterized protein Neighboring gene Pyruvate dehydrogenase kinase Neighboring gene ced-6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel family of mitochondrial proteins is represented by the Drosophila genes slmo, preli-like and real-time. Dee CT, et al. Dev Genes Evol, 2005 May. PMID 15700158
  2. AMPK adapts metabolism to developmental energy requirement during dendrite pruning in Drosophila. Marzano M, et al. Cell Rep, 2021 Nov 16. PMID 34788610
  3. Mitochondrial protein Preli-like is required for development of dendritic arbors and prevents their regression in the Drosophila sensory nervous system. Tsubouchi A, et al. Development, 2009 Nov. PMID 19855018
  4. Mitochondrial dysfunction induces dendritic loss via eIF2α phosphorylation. Tsuyama T, et al. J Cell Biol, 2017 Mar 6. PMID 28209644, Free PMC Article
  5. Identification of a suppressor of retinal degeneration in Drosophila photoreceptors. Georgiev P, et al. J Neurogenet, 2012 Sep. PMID 23043643

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables phosphatidic acid transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrial crista IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrial intermembrane space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
preli-like
Names
CG8806-PB
CG8806-PC
Preli-like
prel-PB
prel-PC
preli
protein of relevant evolutionary and lymphoid interest-like

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9424087..9426107
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273895.1 → NP_001260824.1  preli-like, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260824.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95RE6, Q9V579
    UniProtKB/TrEMBL
    A0A0B4KEN7
    Conserved Domains (1) summary
    pfam04707
    Location:21 → 164
    PRELI; PRELI-like family

  2. NM_136643.4 → NP_610487.3  preli-like, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610487.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95RE6, Q9V579
    UniProtKB/TrEMBL
    A0A0B4KEN7
    Conserved Domains (1) summary
    pfam04707
    Location:21 → 164
    PRELI; PRELI-like family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KEN7 A0A0B4KEN7
Q9V579.3 Q9V579

Gene LinkOut

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