wun wunen [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: wunprovided by FlyBase
Official Full Name: wunenprovided by FlyBase
Primary source: FLYBASE:FBgn0016078
Locus tag: Dmel_CG8804
See related: AllianceGenome:FB:FBgn0016078
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8804; Dmel\CG8804; l(2)k16806; LPP-like; Wun; Wunen
Summary: Enables phosphatase activity. Involved in several processes, including eggshell formation; germ cell repulsion; and septate junction assembly. Located in apical part of cell; lateral plasma membrane; and septate junction. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gland; gut section; and nephrocyte. Orthologous to several human genes including PLPP1 (phospholipid phosphatase 1) and PLPP2 (phospholipid phosphatase 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 45D3-45D4; 2-60 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (9400531..9413463, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (5288036..5300968, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Wunen mutants have cardioblast joining defects and loose pericardial cells in the developing heart.
Title: Drosophila heart cell movement to the midline occurs through both cell autonomous migration and dorsal closure.
The germ cell migratory path can be primarily accounted for by Wunen expression.
Title: Quantifying the range of a lipid phosphate signal in vivo.
germ cell survival and directionality of migration are controlled by two lipid phosphate phosphatases (LPP), wunen (wun) and wunen-2 (wun2). wun wun2 double mutant analysis reveals that the two genes act redundantly in primordial germ cells.
Title: Lipid phosphate phosphatase activity regulates dispersal and bilateral sorting of embryonic germ cells in Drosophila.
Drosophila melanogaster lipid phosphate phosphatases Wunen and Wunen 2 have roles in lateral migration and germ cell elimination
Title: Control of lateral migration and germ cell elimination by the Drosophila melanogaster lipid phosphate phosphatases Wunen and Wunen 2.
there are marked differences in biochemical activity between fly Wun and mammalian lipid phosphate phosphatase (LPPs), with Wun having a narrower activity range than has been reported for the mammalian LPPs
Title: Fly and mammalian lipid phosphate phosphatase isoforms differ in activity both in vitro and in vivo.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c9401450-9401362 mobile_element_type = transposon:INE-1{}3589

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in defense response to Gram-negative bacterium	HMP more info	PubMed
involved_in ectopic germ cell programmed cell death	TAS Traceable Author Statement more info	PubMed
involved_in eggshell formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell migration	IEP Inferred from Expression Pattern more info	PubMed
involved_in germ cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell migration	TAS Traceable Author Statement more info	PubMed
involved_in germ cell repulsion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in germ cell repulsion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell repulsion	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of innate immune response	HMP more info	PubMed
involved_in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipid dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in septate junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in septate junction	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: wunen

Names: CG8804-PA; CG8804-PB; CG8804-PC; Wunen1; wun-PA; wun-PB; wun-PC; wunen 1

NP_001246223.1

EC 3.1.3.-

EC 3.1.3.4

NP_477193.1

EC 3.1.3.-

EC 3.1.3.4

NP_724787.1

EC 3.1.3.-

EC 3.1.3.4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

9400531..9413463 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_165674.3 → NP_724787.1 wunen, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724787.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P91661, Q8MKU5, Q8WT60, Q9U9Y7, Q9V576

UniProtKB/TrEMBL

C7LA91

Related

FBpp0087635

Conserved Domains (1) summary

cd03384
Location:188 → 343

PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
NM_057845.5 → NP_477193.1 wunen, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477193.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9V576

Related

FBpp0087636

Conserved Domains (1) summary

cd03384
Location:109 → 264

PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
NM_001259294.2 → NP_001246223.1 wunen, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246223.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K7K7, C7LA91

Conserved Domains (1) summary

cd03384
Location:188 → 342

PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...