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Non1 Novel nucleolar protein 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35963, updated on 9-Dec-2024

Summary

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Official Symbol
Non1provided by FlyBase
Official Full Name
Novel nucleolar protein 1provided by FlyBase
Primary source
FLYBASE:FBgn0028473
Locus tag
Dmel_CG8801
See related
AllianceGenome:FB:FBgn0028473
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:LD23830; CG30341; CG8801; Dmel\CG8801; LD23830
Summary
Predicted to enable GTPase activity and RNA binding activity. Predicted to be involved in ribosomal large subunit biogenesis. Located in nucleolus. Is expressed in adult head and organism. Orthologous to human GTPBP4 (GTP binding protein 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Non1 in Genome Data Viewer
Location:
45D2-45D3; 2-60 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9396265..9398734, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5283770..5286239, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene lethal (2) 03659 Neighboring gene Outer dynein arm dynein axonemal light chain 1 Neighboring gene lethal (2) k10201 Neighboring gene uncharacterized protein Neighboring gene wunen

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dynamic regulation of ribosome levels and translation during development. Breznak SM, et al. Semin Cell Dev Biol, 2023 Feb 28. PMID 35725716
  2. A translation control module coordinates germline stem cell differentiation with ribosome biogenesis during Drosophila oogenesis. Martin ET, et al. Dev Cell, 2022 Apr 11. PMID 35413237, Free PMC Article
  3. Identification of a suppressor of retinal degeneration in Drosophila photoreceptors. Georgiev P, et al. J Neurogenet, 2012 Sep. PMID 23043643
  4. Hangover Links Nuclear RNA Signaling to cAMP Regulation via the Phosphodiesterase 4d Ortholog dunce. Ruppert M, et al. Cell Rep, 2017 Jan 10. PMID 28076795
  5. A survey of ovary-, testis-, and soma-biased gene expression in Drosophila melanogaster adults. Parisi M, et al. Genome Biol, 2004. PMID 15186491, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ribosomal large subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal large subunit biogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
putative nucleolar protein 1
Names
CG8801-PA
CG8801-PB
Non1-PA
Non1-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9396265..9398734 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299318.1 → NP_001286247.1  putative nucleolar protein 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286247.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V411
    UniProtKB/TrEMBL
    A0A0B4LEY9, C5WLT8
    Conserved Domains (3) summary
    cd01897
    Location:169 → 341
    NOG; Nucleolar GTP-binding protein (NOG)
    COG1084
    Location:5 → 341
    Nog1; GTP-binding protein, GTP1/Obg family [General function prediction only]
    pfam08155
    Location:398 → 448
    NOGCT; NOGCT (NUC087) domain

  2. NM_136640.5 → NP_610484.1  putative nucleolar protein 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610484.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V411
    UniProtKB/TrEMBL
    A0A0B4LEY9, C5WLT8
    Related
    FBpp0087637
    Conserved Domains (3) summary
    cd01897
    Location:169 → 341
    NOG; Nucleolar GTP-binding protein (NOG)
    COG1084
    Location:5 → 341
    Nog1; GTP-binding protein, GTP1/Obg family [General function prediction only]
    pfam08155
    Location:398 → 448
    NOGCT; NOGCT (NUC087) domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LEY9 A0A0B4LEY9
Q9V411.1 Q9V411

Gene LinkOut

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