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Myd88 Myd88 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35956, updated on 4-Jan-2025

Summary

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Official Symbol
Myd88provided by FlyBase
Official Full Name
Myd88provided by FlyBase
Primary source
FLYBASE:FBgn0033402
Locus tag
Dmel_CG2078
See related
AllianceGenome:FB:FBgn0033402
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2078; Dmel\CG2078; DmMyd88; DmMyD88; DMMYD88; dMyd88; dMyD88; dMYd88; dsMyD88; EP(2)2535; kra; Kra; LD20892; MyD8; myd88; MyD88; MYD88; Myd88F
Summary
Enables Toll binding activity; phosphatidylinositol-4,5-bisphosphate binding activity; and signaling adaptor activity. Involved in several processes, including Toll signaling pathway; defense response to other organism; and positive regulation of macromolecule biosynthetic process. Located in cytoplasmic side of plasma membrane. Is expressed in several structures, including anal pad primordium; embryonic anal pad; embryonic/larval midgut; embryonic/larval midgut interstitial cell; and embryonic/larval midgut primordium. Human ortholog(s) of this gene implicated in colorectal cancer (multiple); hepatocellular carcinoma; lung cancer (multiple); lymphoma (multiple); and primary immunodeficiency disease. Orthologous to human MYD88 (MYD88 innate immune signal transduction adaptor). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Myd88 in Genome Data Viewer
Location:
45C5-45C5; 2-60 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9302823..9308722, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5190328..5196227, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Component of oligomeric golgi complex 6 Neighboring gene Mitotic arrest-deficient 1 Neighboring gene DNA fragmentation factor-related protein 2 Neighboring gene long non-coding RNA:CR45918 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mir-987 stem loop Neighboring gene Odorant receptor 45a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Of mice, flies--and men? Comparing fungal infection models for large-scale screening efforts. Brunke S, et al. Dis Model Mech, 2015 May. PMID 25786415, Free PMC Article
  2. The relationship between the preference of mating type (MAT) and source in the opportunistic pathogen Talaromyces marneffei. Qu Q, et al. Med Mycol, 2023 Apr 3. PMID 36931899
  3. Drosophila melanogaster Systemic Infection Model to Study Altered Virulence during Polymicrobial Infection by Aeromonas. Robert A, et al. Pathogens, 2023 Mar 2. PMID 36986327, Free PMC Article
  4. Synthetically engineered Medea gene drive system in the worldwide crop pest Drosophila suzukii. Buchman A, et al. Proc Natl Acad Sci U S A, 2018 May 1. PMID 29666236, Free PMC Article
  5. A negative role for MyD88 in the resistance to starvation as revealed in an intestinal infection of Drosophila melanogaster with the Gram-positive bacterium Staphylococcus xylosus. Ayyaz A, et al. Immunobiology, 2013 Apr. PMID 23083631

See all (232) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. An unusual Toll/MyD88-mediated Drosophila host defence against Talaromyces marneffei.
    Title: An unusual Toll/MyD88-mediated Drosophila host defence against Talaromyces marneffei.
  2. a novel function of MyD88 in the regulation of metabolism that appears to be independent of its known roles in immunity and development.
    Title: A negative role for MyD88 in the resistance to starvation as revealed in an intestinal infection of Drosophila melanogaster with the Gram-positive bacterium Staphylococcus xylosus.
  3. propose that dMyD88 is the functional homolog of TIRAP and that both proteins function as sorting adaptors to recruit downstream signaling adaptors to activated receptors
    Title: Phosphoinositide binding by the Toll adaptor dMyD88 controls antibacterial responses in Drosophila.
  4. both the heterodimeric and heterotrimeric complexes form kidney-shaped structures and that Tube is bivalent and has separate high affinity binding sites for dMyD88 and Pelle.
    Title: Assembly of oligomeric death domain complexes during Toll receptor signaling.
  5. DmMyD88 encodes an essential component of the Toll pathway in dorsoventral pattern formation.
    Title: DmMyD88 controls dorsoventral patterning of the Drosophila embryo.
  6. We show that there is a direct interaction between Kra and Tube presumably mediated by the death domains present in both proteins.
    Title: Krapfen/dMyd88 is required for the establishment of dorsoventral pattern in the Drosophila embryo.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables TIR domain binding IEA
Inferred from Electronic Annotation
more info
  
enables Toll binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables Toll binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables Toll-like receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling adaptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in Toll signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Toll signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in Toll signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in antifungal humoral response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to fungus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dorsal/ventral axis specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dorsal/ventral pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of antifungal peptide production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of antimicrobial peptide production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to mycotoxin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to tumor cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in toll-like receptor 4 signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Myd88
Names
CG2078-PA
CG2078-PB
CG2078-PC
MyD88
Myd88-PA
Myd88-PB
Myd88-PC
Myd88F
dMyD88
krapfen

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9302823..9308722 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273892.1 → NP_001260821.1  Myd88, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260821.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K105
    Conserved Domains (2) summary
    cl14633
    Location:90 → 172
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl23749
    Location:242 → 375
    TIR_2; TIR domain

  2. NM_136635.3 → NP_610479.1  Myd88, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610479.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K105
    Related
    FBpp0087679
    Conserved Domains (2) summary
    cl14633
    Location:90 → 172
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl23749
    Location:242 → 375
    TIR_2; TIR domain

  3. NM_001299317.1 → NP_001286246.1  Myd88, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286246.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K105
    Conserved Domains (2) summary
    cl14633
    Location:90 → 172
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl23749
    Location:242 → 375
    TIR_2; TIR domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K105 Q7K105

Gene LinkOut

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