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Gnptab N-acetylglucosamine-1-phosphate transferase subunits alpha and beta [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35943, updated on 9-Dec-2024

Summary

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Official Symbol
Gnptabprovided by FlyBase
Official Full Name
N-acetylglucosamine-1-phosphate transferase subunits alpha and betaprovided by FlyBase
Primary source
FLYBASE:FBgn0033392
Locus tag
Dmel_CG8027
See related
AllianceGenome:FB:FBgn0033392
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Cg8027; CG8027; Dmel\CG8027; DmGNPTAB; GNPTAB; Gntap
Summary
Predicted to enable UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity. Predicted to be involved in N-glycan processing to lysosome. Predicted to be active in Golgi membrane. Is expressed in organism. Human ortholog(s) of this gene implicated in mucolipidosis II alpha/beta and mucolipidosis III alpha/beta. Orthologous to human GNPTAB (N-acetylglucosamine-1-phosphate transferase subunits alpha and beta). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Gnptab in Genome Data Viewer
Location:
45B3-45B4; 2-60 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9204410..9207124, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5091915..5094629, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene unplugged Neighboring gene Vacuolar H[+] ATPase AC45 accessory subunit Neighboring gene long non-coding RNA:CR45309

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural insights into how GlcNAc-1-phosphotransferase directs lysosomal protein transport. Du S, et al. J Biol Chem, 2022 Mar. PMID 35148990, Free PMC Article
  2. Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity. Yu M, et al. PLoS Genet, 2023 May. PMID 37200393, Free PMC Article
  3. RNAi screen identifies a role for adaptor protein AP-3 in sorting to the regulated secretory pathway. Asensio CS, et al. J Cell Biol, 2010 Dec 13. PMID 21149569, Free PMC Article
  4. An expanded toolkit for Drosophila gene tagging using synthesized homology donor constructs for CRISPR-mediated homologous recombination. Kanca O, et al. Elife, 2022 Jun 20. PMID 35723254, Free PMC Article
  5. Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functions. Erives AJ. Dev Genes Evol, 2015 Sep. PMID 26173873, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity ISM
Inferred from Sequence Model
more info
 PubMed 
enables transferase activity, transferring phosphorus-containing groups IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-glycan processing to lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in N-glycan processing to lysosome ISM
Inferred from Sequence Model
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in Golgi membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
N-acetylglucosamine-1-phosphate transferase subunits alpha and beta
Names
CG8027-PA
Gnptab-PA
NP_610469.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9204410..9207124 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136625.3 → NP_610469.3  N-acetylglucosamine-1-phosphate transferase subunits alpha and beta [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610469.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7S7, Q8SXI4
    Related
    FBpp0087690
    Conserved Domains (5) summary
    pfam00066
    Location:206 → 240
    Notch; LNR domain
    pfam11380
    Location:93 → 200
    Stealth_CR2; Stealth protein CR2, conserved region 2
    pfam17101
    Location:64 → 90
    Stealth_CR1; Stealth protein CR1, conserved region 1
    pfam17102
    Location:374 → 422
    Stealth_CR3; Stealth protein CR3, conserved region 3
    pfam17103
    Location:561 → 616
    Stealth_CR4; Stealth protein CR4, conserved region 4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z7S7 A1Z7S7
Q8SXI4 Q8SXI4

Gene LinkOut

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