Rab32 Rab32 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Rab32provided by FlyBase
Official Full Name: Rab32provided by FlyBase
Primary source: FLYBASE:FBgn0002567
Locus tag: Dmel_CG8024
See related: AllianceGenome:FB:FBgn0002567
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 24652026; 24652028; A1Z7S1; anon-WO0118547.106; beck; CG8024; Dmel\CG8024; DmRab32; DRABR1; DrabRP1; ltd; Ltd; Rab-r1; Rab-RP1; RAB-RP1; Rab-RP1/CG8024; rab32; Rab32/RP1; RAB7L; Rab7L1; RabRP1
Summary: Predicted to enable GTPase activity. Involved in several processes, including compound eye pigmentation; eye pigment granule organization; and ommochrome biosynthetic process. Located in autophagosome and lysosome. Is active in mitochondrial outer membrane. Is expressed in several structures, including Malpighian tubule primordium; adult head; adult optic lobe; brain; and photoreceptor. Used to study Parkinson's disease. Orthologous to human RAB32 (RAB32, member RAS oncogene family). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 45B2-45B3; 2-60 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (9177864..9186342, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (5065369..5073847, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Vesicular transport mediates the uptake of cytoplasmic proteins into mitochondria in Drosophila melanogaster.
Title: Vesicular transport mediates the uptake of cytoplasmic proteins into mitochondria in Drosophila melanogaster.
data suggest that RABRP1 is involved in the lysosomal vesicle transport pathway, including the biogenesis or degradation of pigment granules
Title: Molecular and functional characterization of a unique Rab protein, RABRP1, containing the WDIAGQE sequence in a GTPase motif.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Rab protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in compound eye pigmentation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in eye pigment granule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in melanosome organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ommochrome biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of lipid storage	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in autophagosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in recycling endosome	HDA more info	PubMed
located_in synapse	HDA more info	PubMed
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network	IEA Inferred from Electronic Annotation more info
located_in vesicle	IEA Inferred from Electronic Annotation more info
located_in vesicle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Rab32

Names: CG8024-PB; CG8024-PC; CG8024-PD; CG8024-PE; CG8024-PH; CG8024-PI; CG8024-PJ; Rab-related protein 1; Rab32-PB; Rab32-PC; Rab32-PD; Rab32-PE; Rab32-PH; Rab32-PI; Rab32-PJ; lightoid

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

9177864..9186342 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_165658.2 → NP_724763.1 Rab32, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724763.1

Status: REVIEWED

UniProtKB/TrEMBL

A1Z7S1, Q86PD0

Related

FBpp0088872

Conserved Domains (2) summary

smart00175
Location:20 → 188

RAB; Rab subfamily of small GTPases

cd04107
Location:20 → 222

Rab32_Rab38; Rab GTPase families 18 (Rab18) and 32 (Rab32)
NM_165660.2 → NP_724765.1 Rab32, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724765.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8T0G8

Related

FBpp0088871

Conserved Domains (2) summary

smart00175
Location:186 → 354

RAB; Rab subfamily of small GTPases

cd04107
Location:186 → 388

Rab32_Rab38; Rab GTPase families 18 (Rab18) and 32 (Rab32)
NM_165659.2 → NP_724764.1 Rab32, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724764.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8T0G8

Related

FBpp0088873

Conserved Domains (2) summary

smart00175
Location:186 → 354

RAB; Rab subfamily of small GTPases

cd04107
Location:186 → 388

Rab32_Rab38; Rab GTPase families 18 (Rab18) and 32 (Rab32)
NM_001299309.1 → NP_001286238.1 Rab32, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286238.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LEY0, Q86PD0

Conserved Domains (2) summary

smart00175
Location:12 → 180

RAB; Rab subfamily of small GTPases

cd04107
Location:12 → 214

Rab32_Rab38; Rab GTPase families 18 (Rab18) and 32 (Rab32)
NM_080370.4 → NP_525109.1 Rab32, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_525109.1

Status: REVIEWED

UniProtKB/TrEMBL

A1Z7S3

Related

FBpp0088870

Conserved Domains (2) summary

smart00175
Location:484 → 652

RAB; Rab subfamily of small GTPases

cd04107
Location:484 → 686

Rab32_Rab38; Rab GTPase families 18 (Rab18) and 32 (Rab32)
NM_165663.3 → NP_724768.3 Rab32, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724768.3

Status: REVIEWED

UniProtKB/TrEMBL

A1Z7S2

Conserved Domains (2) summary

smart00175
Location:187 → 355

RAB; Rab subfamily of small GTPases

cd04107
Location:187 → 389

Rab32_Rab38; Rab GTPase families 18 (Rab18) and 32 (Rab32)
NM_001299308.1 → NP_001286237.1 Rab32, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286237.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LEY0, Q86PD0

Conserved Domains (2) summary

smart00175
Location:12 → 180

RAB; Rab subfamily of small GTPases

cd04107
Location:12 → 214

Rab32_Rab38; Rab GTPase families 18 (Rab18) and 32 (Rab32)