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Rad51D Rad51 recombinase D [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35937, updated on 4-Jan-2025

Summary

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Official Symbol
Rad51Dprovided by FlyBase
Official Full Name
Rad51 recombinase Dprovided by FlyBase
Primary source
FLYBASE:FBgn0033389
Locus tag
Dmel_CG2412
See related
AllianceGenome:FB:FBgn0033389
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2412; Dm CG2412; Dmel\CG2412; dmRad51C; Rad51; Rad51C
Summary
Predicted to enable ATP-dependent DNA damage sensor activity; DNA strand exchange activity; and single-stranded DNA binding activity. Predicted to contribute to four-way junction DNA binding activity. Predicted to be involved in DNA metabolic process. Predicted to be part of Rad51B-Rad51C-Rad51D-XRCC2 complex. Predicted to be active in microtubule organizing center and replication fork. Human ortholog(s) of this gene implicated in hereditary breast ovarian cancer syndrome. Orthologous to human RAD51D (RAD51 paralog D). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Rad51D in Genome Data Viewer
Location:
45B1-45B1; 2-60 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9165632..9167670)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5053137..5055175)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44283 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Receptor mediated endocytosis 8 Neighboring gene Rab32 Neighboring gene long non-coding RNA:CR44284

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. [Epigenetic effect of the rad201(G1) mutation in a system with mobilization of nonautonomous P elements in Drosophila]. Khromykh IuM, et al. Genetika, 2008 Mar. PMID 18664138
  2. Persistent DNA damage signaling and DNA polymerase theta promote broken chromosome segregation. Clay DE, et al. J Cell Biol, 2021 Dec 6. PMID 34613334, Free PMC Article
  3. The Drosophila spn-D gene encodes a RAD51C-like protein that is required exclusively during meiosis. Abdu U, et al. Genetics, 2003 Sep. PMID 14504227, Free PMC Article
  4. Evolutionary dynamics of recently duplicated genes: Selective constraints on diverging paralogs in the Drosophila pseudoobscura genome. Meisel RP. J Mol Evol, 2009 Jul. PMID 19536449
  5. Evolutionary and functional analysis of the invariant SWIM domain in the conserved Shu2/SWS1 protein family from Saccharomyces cerevisiae to Homo sapiens. Godin SK, et al. Genetics, 2015 Apr. PMID 25659377, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP-dependent DNA damage sensor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ATP-dependent activity, acting on DNA IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA strand exchange activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
contributes_to four-way junction DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA recombination ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in DNA repair ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in DNA strand invasion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in reciprocal meiotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in telomere maintenance IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Rad51B-Rad51C-Rad51D-XRCC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in replication fork IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Rad51 recombinase D
Names
CG2412-PB
Rad51C
Rad51D-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9165632..9167670
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136622.3 → NP_610466.2  Rad51 recombinase D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610466.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7R8, H0RNP1
    Conserved Domains (2) summary
    PRK09361
    Location:80 → 335
    radB; DNA repair and recombination protein RadB; Provisional
    cl21455
    Location:80 → 336
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z7R8 A1Z7R8

Gene LinkOut

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