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Prp38 pre-mRNA processing factor 38 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35934, updated on 9-Dec-2024

Summary

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Official Symbol
Prp38provided by FlyBase
Official Full Name
pre-mRNA processing factor 38provided by FlyBase
Primary source
FLYBASE:FBgn0050342
Locus tag
Dmel_CG30342
See related
AllianceGenome:FB:FBgn0050342
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG30342; CG8054; Dmel\CG30342; dprp38; prp38
Summary
Involved in mRNA splicing, via spliceosome and regulation of G2/M transition of mitotic cell cycle. Part of protein-containing complex. Is expressed in larval midline neurons and organism. Orthologous to human PRPF38A (pre-mRNA processing factor 38A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Prp38 in Genome Data Viewer
Location:
45A12-45A12; 2-60 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9143956..9145151)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5031461..5032656)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene shrub Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Perturbation of U2AF65/NXF1-mediated RNA nuclear export enhances RNA toxicity in polyQ diseases. Tsoi H, et al. Hum Mol Genet, 2011 Oct 1. PMID 21725067
  2. Prp22 and spliceosome components regulate chromatin dynamics in germ-line polyploid cells. Klusza S, et al. PLoS One, 2013. PMID 24244416, Free PMC Article
  3. The splicing co-factor Barricade/Tat-SF1 is required for cell cycle and lineage progression in Drosophila neural stem cells. Abramczuk MK, et al. Development, 2017 Nov 1. PMID 28935704
  4. Prp8 regulates oncogene-induced hyperplastic growth in Drosophila. Fernández-Espartero CH, et al. Development, 2018 Nov 12. PMID 30333215, Free PMC Article
  5. Drosophila MFAP1 is required for pre-mRNA processing and G2/M progression. Andersen DS, et al. J Biol Chem, 2008 Nov 7. PMID 18765666, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome HDA PubMed 
part_of precatalytic spliceosome HDA PubMed 
part_of precatalytic spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
pre-mRNA processing factor 38
Names
CG30342-PA
Prp38-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9143956..9145151
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136619.3 → NP_610463.2  pre-mRNA processing factor 38 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610463.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7JVL3
    Related
    FBpp0087663
    Conserved Domains (1) summary
    pfam03371
    Location:10 → 172
    PRP38; PRP38 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JVL3.1 Q7JVL3

Gene LinkOut

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