U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CG18659 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35929, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
CG18659provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0027561
Locus tag
Dmel_CG18659
See related
AllianceGenome:FB:FBgn0027561
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.140; anon-WO0118547.145; BcDNA:GH08789; CG30347; CG30348; CG8059; Dmel\CG18659
Summary
Predicted to enable guanyl-nucleotide exchange factor activity and phosphatidylinositol phosphate binding activity. Predicted to be involved in endocytic recycling; endocytosis; and regulation of Rab protein signal transduction. Predicted to be located in clathrin-coated vesicle. Predicted to be active in cytosol and intracellular membrane-bounded organelle. Is expressed in adult head and organism. Orthologous to human DENND1A (DENN domain containing 1A); DENND1B (DENN domain containing 1B); and DENND1C (DENN domain containing 1C). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See CG18659 in Genome Data Viewer
Location:
45A9-45A10; 2-60 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9123304..9132030, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5010809..5019535, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Suppressor of variegation 2-10 Neighboring gene Phosphorylated adaptor for RNA export Neighboring gene Glutathione S transferase E13 Neighboring gene alpha/beta hydrolase 1 Neighboring gene alicorn Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. uDENN, DENN, and dDENN: indissociable domains in Rab and MAP kinases signaling pathways. Levivier E, et al. Biochem Biophys Res Commun, 2001 Sep 28. PMID 11563850
  2. HITS-CLIP reveals sex-differential RNA binding and alterative splicing regulation of SRm160 in Drosophila. Qiu C, et al. J Mol Cell Biol, 2019 Feb 1. PMID 29750417, Free PMC Article
  3. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. Yoshimura S, et al. J Cell Biol, 2010 Oct 18. PMID 20937701, Free PMC Article
  4. Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster. Krauchunas AR, et al. Dev Biol, 2012 Oct 1. PMID 22884528, Free PMC Article
  5. Proteomic and functional genomic landscape of receptor tyrosine kinase and ras to extracellular signal-regulated kinase signaling. Friedman AA, et al. Sci Signal, 2011 Oct 25. PMID 22028469, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylinositol phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of Rab protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in clathrin-coated vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
uncharacterized protein
Names
CG18659-PA
CG18659-PC
CG18659-PD
CG18659-PE
CG18659-PF
CG18659-PH
CG18659-PI

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9123304..9132030 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259287.2 → NP_001246216.2  uncharacterized protein Dmel_CG18659, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246216.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K840, E4NKI4
    Conserved Domains (3) summary
    smart00801
    Location:315 → 379
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:10 → 95
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:98 → 282
    DENN; DENN (AEX-3) domain

  2. NM_001201961.2 → NP_001188890.1  uncharacterized protein Dmel_CG18659, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188890.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4JD58
    Conserved Domains (3) summary
    smart00801
    Location:315 → 379
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:10 → 95
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:98 → 282
    DENN; DENN (AEX-3) domain

  3. NM_001259289.2 → NP_001246218.1  uncharacterized protein Dmel_CG18659, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246218.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C8VV76
    Conserved Domains (3) summary
    smart00801
    Location:315 → 379
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:10 → 95
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:98 → 282
    DENN; DENN (AEX-3) domain

  4. NM_001201962.2 → NP_001188891.1  uncharacterized protein Dmel_CG18659, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188891.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4JD05
    Conserved Domains (3) summary
    smart00801
    Location:315 → 379
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:10 → 95
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:98 → 282
    DENN; DENN (AEX-3) domain

  5. NM_136614.6 → NP_610458.2  uncharacterized protein Dmel_CG18659, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610458.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7Q6
    Conserved Domains (3) summary
    smart00801
    Location:315 → 379
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:10 → 95
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:98 → 282
    DENN; DENN (AEX-3) domain

  6. NM_145873.4 → NP_665880.2  uncharacterized protein Dmel_CG18659, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_665880.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7Q5
    Related
    FBpp0087707
    Conserved Domains (3) summary
    smart00801
    Location:315 → 379
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:10 → 95
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:98 → 282
    DENN; DENN (AEX-3) domain

  7. NM_001259288.2 → NP_001246217.1  uncharacterized protein Dmel_CG18659, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246217.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K840, E4NKI4
    Conserved Domains (3) summary
    smart00801
    Location:315 → 379
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:10 → 95
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:98 → 282
    DENN; DENN (AEX-3) domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4JD05 A0A0B4JD05
A0A0B4JD58 A0A0B4JD58
A0A0B4K840 A0A0B4K840
A1Z7Q5 A1Z7Q5
A1Z7Q6 A1Z7Q6
C8VV76 C8VV76
Q7KMK4 Q7KMK4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous