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Ctu1 Cytosolic thiouridylase subunit 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35920, updated on 4-Jan-2025

Summary

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Official Symbol
Ctu1provided by FlyBase
Official Full Name
Cytosolic thiouridylase subunit 1provided by FlyBase
Primary source
FLYBASE:FBgn0033375
Locus tag
Dmel_CG8078
See related
AllianceGenome:FB:FBgn0033375
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.76; CG8078; Dmel\CG8078
Summary
Predicted to enable sulfurtransferase activity and tRNA binding activity. Predicted to be involved in tRNA wobble position uridine thiolation. Predicted to be located in cytosol. Predicted to be part of cytosolic tRNA wobble base thiouridylase complex. Is expressed in embryonic/larval salivary gland body; organism; and salivary gland body primordium. Orthologous to human CTU1 (cytosolic thiouridylase subunit 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Ctu1 in Genome Data Viewer
Location:
45A3-45A3; 2-60 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9096931..9098525, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4984436..4986030, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene U snoRNA host gene 4 Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene Van Gogh

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Elongator stabilizes microtubules to control central spindle asymmetry and polarized trafficking of cell fate determinants. Planelles-Herrero VJ, et al. Nat Cell Biol, 2022 Nov. PMID 36302967, Free PMC Article
  2. A computational search for box C/D snoRNA genes in the Drosophila melanogaster genome. Accardo MC, et al. Bioinformatics, 2004 Dec 12. PMID 15247100
  3. Genome-wide mapping of boundary element-associated factor (BEAF) binding sites in Drosophila melanogaster links BEAF to transcription. Jiang N, et al. Mol Cell Biol, 2009 Jul. PMID 19380483, Free PMC Article
  4. Regulation of Drosophila mesoderm migration by phosphoinositides and the PH domain of the Rho GTP exchange factor Pebble. Murray MJ, et al. Dev Biol, 2012 Dec 1. PMID 23000359
  5. Phenotypes Associated with Second Chromosome P Element Insertions in Drosophila melanogaster. Kahsai L, et al. G3 (Bethesda), 2016 Aug 9. PMID 27317776, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables sulfurtransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in tRNA thio-modification IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA thio-modification ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in tRNA wobble position uridine thiolation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA wobble uridine modification IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA wobble uridine modification ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of cytosolic tRNA wobble base thiouridylase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cytosolic thiouridylase subunit 1
Names
CG8078-PA
Ctu1-PA
NP_610451.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9096931..9098525 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136607.2 → NP_610451.1  cytosolic thiouridylase subunit 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610451.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7JWW5
    Related
    FBpp0087712
    Conserved Domains (3) summary
    TIGR00269
    Location:203 → 304
    TIGR00269; TIGR00269 family protein
    COG0037
    Location:28 → 311
    TilS; tRNA(Ile)-lysidine synthase TilS/MesJ [Translation, ribosomal structure and biogenesis]
    cd01993
    Location:52 → 239
    Alpha_ANH_like_II; This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JWW5.1 Q7JWW5

Gene LinkOut

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