U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

FANCI Fanconi anemia complementation group I [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35895, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
FANCIprovided by FlyBase
Official Full Name
Fanconi anemia complementation group Iprovided by FlyBase
Primary source
FLYBASE:FBgn0033354
Locus tag
Dmel_CG13745
See related
AllianceGenome:FB:FBgn0033354
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG13745; Dmel\CG13745; fanci
Summary
Predicted to enable DNA polymerase binding activity. Predicted to be involved in DNA repair. Human ortholog(s) of this gene implicated in Fanconi anemia; Fanconi anemia complementation group I; and female breast cancer. Orthologous to human FANCI (FA complementation group I). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See FANCI in Genome Data Viewer
Location:
44F9-44F9; 2-59 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8934576..8939789, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4822081..4827294, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Poly(A)-binding protein-dependent poly(A) ribonuclease 2 Neighboring gene Baramicin B Neighboring gene long non-coding RNA:CR44273 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The structure of the catalytic subunit FANCL of the Fanconi anemia core complex. Cole AR, et al. Nat Struct Mol Biol, 2010 Mar. PMID 20154706, Free PMC Article
  2. Proliferation of Double-Strand Break-Resistant Polyploid Cells Requires Drosophila FANCD2. Bretscher HS, et al. Dev Cell, 2016 Jun 6. PMID 27270041, Free PMC Article
  3. Sustained inactivation of the Polycomb PRC1 complex induces DNA repair defects and genomic instability in epigenetic tumors. Rawal CC, et al. Histochem Cell Biol, 2024 Jul. PMID 38888809, Free PMC Article
  4. The DHR96 nuclear receptor controls triacylglycerol homeostasis in Drosophila. Sieber MH, et al. Cell Metab, 2009 Dec. PMID 19945405, Free PMC Article
  5. Effect of Larval Nutrition on Maternal mRNA Contribution to the Drosophila Egg. Crofton AE, et al. G3 (Bethesda), 2018 May 31. PMID 29666195, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA polymerase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
fanconi anemia complementation group I
Names
CG13745-PA
FANCI-PA
fanconi anemia complementation group I homologue

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    8934576..8939789 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136585.3 → NP_610429.2  fanconi anemia complementation group I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610429.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1Z7L1
    UniProtKB/TrEMBL
    Q29QV6
    Conserved Domains (1) summary
    cd11720
    Location:37 → 1293
    FANCI; Fanconi anemia I protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z7L1 A1Z7L1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous