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Sec31 Secretory 31 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35877, updated on 9-Dec-2024

Summary

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Official Symbol
Sec31provided by FlyBase
Official Full Name
Secretory 31provided by FlyBase
Primary source
FLYBASE:FBgn0033339
Locus tag
Dmel_CG8266
See related
AllianceGenome:FB:FBgn0033339
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8266; Dmel\CG8266; dSec31p; sec31; SEC31; SEC31A
Summary
Predicted to enable structural molecule activity. Involved in defense response to Gram-negative bacterium and positive regulation of innate immune response. Located in Golgi stack and endoplasmic reticulum exit site. Is expressed in adult head. Used to study Halperin-Birk syndrome. Human ortholog(s) of this gene implicated in Halperin-Birk syndrome. Orthologous to human SEC31A (SEC31 homolog A, COPII coat complex component) and SEC31B (SEC31 homolog B, COPII coat complex component). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Sec31 in Genome Data Viewer
Location:
44F3-44F3; 2-59 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8893613..8898798)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4781118..4786303)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Dynactin 2, p50 subunit Neighboring gene antisense RNA:CR45202 Neighboring gene anastral spindle 2 Neighboring gene uncharacterized protein Neighboring gene MRG/MORF4L binding protein Neighboring gene G protein gamma subunit 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SEC31A mutation affects ER homeostasis, causing a neurological syndrome. Halperin D, et al. J Med Genet, 2019 Mar. PMID 30464055
  2. Drosophila Sec16 mediates the biogenesis of tER sites upstream of Sar1 through an arginine-rich motif. Ivan V, et al. Mol Biol Cell, 2008 Oct. PMID 18614796, Free PMC Article
  3. Cut, via CrebA, transcriptionally regulates the COPII secretory pathway to direct dendrite development in Drosophila. Iyer SC, et al. J Cell Sci, 2013 Oct 15. PMID 23902691, Free PMC Article
  4. Alcohol Activates Scabrous-Notch to Influence Associated Memories. Petruccelli E, et al. Neuron, 2018 Dec 5. PMID 30482693, Free PMC Article
  5. Essential Role of COPII Proteins in Maintaining the Contractile Ring Anchoring to the Plasma Membrane during Cytokinesis in Drosophila Male Meiosis. Matsuura Y, et al. Int J Mol Sci, 2024 Apr 20. PMID 38674111, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables structural molecule activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural molecule activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in COPII-coated vesicle budding ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in COPII-coated vesicle cargo loading IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to Gram-negative bacterium HMP PubMed 
involved_in endoplasmic reticulum organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of innate immune response HMP PubMed 
Component Evidence Code Pubs
part_of COPII vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COPII vesicle coat ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in COPII-coated ER to Golgi transport vesicle TAS
Traceable Author Statement
more info
 PubMed 
located_in Golgi stack IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum exit site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum exit site IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
secretory 31
Names
CG8266-PA
CG8266-PB
CG8266-PC
CG8266-PD
Sec31 ortholog
Sec31-PA
Sec31-PB
Sec31-PC
Sec31-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    8893613..8898798
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299286.1 → NP_001286215.1  secretory 31, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286215.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LEZ1, Q5U0U9
    Conserved Domains (5) summary
    COG2319
    Location:35 → 334
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:11 → 61
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:80 → 329
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl14807
    Location:570 → 690
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    cl23782
    Location:811 → 873
    RCR; Chitin synthesis regulation, resistance to Congo red

  2. NM_001299285.1 → NP_001286214.1  secretory 31, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286214.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LEY1, Q5U0U9
    Conserved Domains (5) summary
    COG2319
    Location:35 → 334
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:11 → 61
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:80 → 329
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl14807
    Location:569 → 689
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    cl23782
    Location:810 → 872
    RCR; Chitin synthesis regulation, resistance to Congo red

  3. NM_165630.3 → NP_724716.1  secretory 31, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724716.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7J6, Q5U0U9
    Related
    FBpp0087724
    Conserved Domains (5) summary
    COG2319
    Location:35 → 334
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:11 → 61
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:80 → 329
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl14807
    Location:551 → 671
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    cl23782
    Location:792 → 854
    RCR; Chitin synthesis regulation, resistance to Congo red

  4. NM_136570.4 → NP_610414.1  secretory 31, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610414.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7J7, Q5U0U9
    Related
    FBpp0087723
    Conserved Domains (5) summary
    COG2319
    Location:35 → 334
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:11 → 61
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:80 → 329
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl14807
    Location:550 → 670
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    cl23782
    Location:791 → 853
    RCR; Chitin synthesis regulation, resistance to Congo red
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LEY1 A0A0B4LEY1
A0A0B4LEZ1 A0A0B4LEZ1
A1Z7J6 A1Z7J6
A1Z7J7 A1Z7J7
Q5U0U9 Q5U0U9
Q961K5 Q961K5

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