U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

stmA stambha A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35865, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
stmAprovided by FlyBase
Official Full Name
stambha Aprovided by FlyBase
Primary source
FLYBASE:FBgn0086784
Locus tag
Dmel_CG8739
See related
AllianceGenome:FB:FBgn0086784
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8739; cmp44E; Dmel\CG8739; rbo; Rbo; RBO; stambhA; stm-A; StmA
Summary
Involved in bulk synaptic vesicle endocytosis; phototransduction; and synaptic vesicle exocytosis. Located in synapse. Is expressed in several structures, including adult antennal lobe; adult mushroom body; embryonic brain; germline cell; and organism subdivision. Orthologous to several human genes including EFR3B (EFR3 homolog B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See stmA in Genome Data Viewer
Location:
44E3-44E3; 2-59 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8729502..8734304, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4617007..4621809, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene germ cell-less Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene bloated Neighboring gene long non-coding RNA:CR44277

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Effects of mutations at the stambh A locus of Drosophila melanogaster. Kumar M, et al. J Genet, 2001 Aug. PMID 11910128
  2. Studies on paralysis and development of second chromosome temperature sensitive paralytic mutants of Drosophila melanogaster. Shyngle J, et al. Indian J Exp Biol, 1985 May. PMID 3935574
  3. Phenotypes of lethal alleles of the recessive temperature sensitive paralytic mutant stambh A of Drosophila melanogaster suggest its neurogenic function. Chandrashekaran S, et al. Genetica, 1993. PMID 8150294
  4. Clonal analysis of cmp44E, which encodes a conserved putative transmembrane protein, indicates a requirement for cell viability in Drosophila. Faulkner DL, et al. Dev Genet, 1998. PMID 9883579
  5. Rolling blackout, a newly identified PIP2-DAG pathway lipase required for Drosophila phototransduction. Huang FD, et al. Nat Neurosci, 2004 Oct. PMID 15361878

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study suggests the RBO-PI4KIIIalpha complex as a novel therapeutic target, and PI4KIIIalpha inhibitors as new drug candidates.
    Title: Downregulation of RBO-PI4KIIIα Facilitates Aβ(42) Secretion and Ameliorates Neural Deficits in Aβ(42)-Expressing Drosophila.
  2. This study showed that mutants in the gene stambhA (stmA),which encodes a phosphatidylinositol 4,5 bisphosphate-diacylglycerol lipase, exhibit reduction in the amplitudes of odor-evoked responses recorded from the antennal surface of adult Drosophila.
    Title: Drosophila mutants in phospholipid signaling have reduced olfactory responses as adults and larvae.
  3. Rolling blackout protein possesses both lipase domain-dependent and scaffolding functions with differential requirements in non-neuronal versus neuronal endocytosis mechanisms downstream of dynamin GTPase activity.
    Title: Drosophila rolling blackout displays lipase domain-dependent and -independent endocytic functions downstream of dynamin.
  4. The rolling blackout (rbo) gene encodes an integral plasma membrane lipase required for Drosophila phototransduction.
    Title: Rolling blackout, a newly identified PIP2-DAG pathway lipase required for Drosophila phototransduction.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in bulk synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phototransduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
stambha A
Names
CG8739-PA
CG8739-PB
CG8739-PC
CG8739-PD
CG8739-PE
CG8739-PF
conserved membrane protein at 44E
rolling blackout
stambh A
stambhA
stmA-PA
stmA-PB
stmA-PC
stmA-PD
stmA-PE
stmA-PF

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    8729502..8734304 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165624.2 → NP_724710.1  stambha A, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724710.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IGJ0
    Related
    FBpp0087794

  2. NM_001014513.2 → NP_001014513.1  stambha A, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014513.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1Z7I7, A1Z7I8, A1Z7I9, O96648, Q7K2E8, Q8IGJ0

  3. NM_165625.2 → NP_724711.1  stambha A, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724711.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IGJ0
    Related
    FBpp0087795

  4. NM_001299282.1 → NP_001286211.1  stambha A, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286211.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LFU5

  5. NM_001382198.1 → NP_001369066.1  stambha A, isoform E [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A6M3Q7F3

  6. NM_001382199.1 → NP_001369067.1  stambha A, isoform F [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A6M3Q6Z1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LFU5 A0A0B4LFU5
A0A6M3Q6Z1 A0A6M3Q6Z1
A0A6M3Q7F3 A0A6M3Q7F3
Q8IGJ0.3 Q8IGJ0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools