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rgr regular [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35843, updated on 9-Dec-2024

Summary

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Official Symbol
rgrprovided by FlyBase
Official Full Name
regularprovided by FlyBase
Primary source
FLYBASE:FBgn0267792
Locus tag
Dmel_CG8643
See related
AllianceGenome:FB:FBgn0267792
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14751; CG8643; Dmel\CG8643; l(2)k02605
Summary
Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in embryonic/larval posterior spiracle; mesoderm; and pole plasm. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See rgr in Genome Data Viewer
Location:
44D4-44D4; 2-59 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8600415..8612295)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4487920..4499800)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Lunapark Neighboring gene uncharacterized protein Neighboring gene Calcium-independent receptor for alpha-latrotoxin Neighboring gene Vacuolar protein sorting 25

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A P element with a novel fusion of reporters identifies regular, a C2H2 zinc-finger gene downstream of the circadian clock. Scully AL, et al. Mol Cell Neurosci, 2002 Apr. PMID 11988018
  2. Notch cooperates with Lozenge/Runx to lock haemocytes into a differentiation programme. Terriente-Felix A, et al. Development, 2013 Feb. PMID 23325760, Free PMC Article
  3. Molecular characterization of teflon, a gene required for meiotic autosome segregation in male Drosophila melanogaster. Arya GH, et al. Genetics, 2006 Sep. PMID 16816414, Free PMC Article
  4. The Drosophila STAM gene homolog is in a tight gene cluster, and its expression correlates to that of the adjacent gene ial. Mesilaty-Gross S, et al. Gene, 1999 Apr 29. PMID 10231582
  5. The negative elongation factor NELF promotes induced transcriptional response of Drosophila ecdysone-dependent genes. Mazina MY, et al. Sci Rep, 2021 Jan 8. PMID 33420323, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription ISM
Inferred from Sequence Model
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
regular
Names
CG8643-PA
CG8643-PC
lethal (2) k02605
rgr-PA
rgr-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    8600415..8612295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001169618.2 → NP_001163089.2  regular, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163089.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JH10
    Conserved Domains (4) summary
    COG5048
    Location:742 → 824
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:719 → 739
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam10545
    Location:335 → 420
    MADF_DNA_bdg; Alcohol dehydrogenase transcription factor Myb/SANT-like
    pfam13465
    Location:763 → 784
    zf-H2C2_2; Zinc-finger double domain

  2. NM_165611.3 → NP_724690.1  regular, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724690.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KG36
    Related
    FBpp0087772
    Conserved Domains (4) summary
    COG5048
    Location:709 → 791
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:686 → 706
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam10545
    Location:302 → 387
    MADF_DNA_bdg; Alcohol dehydrogenase transcription factor Myb/SANT-like
    pfam13465
    Location:730 → 751
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1JH10 E1JH10
Q5U0W3 Q5U0W3
Q7KG36 Q7KG36

Gene LinkOut

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