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mtt mangetout [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35832, updated on 4-Jan-2025

Summary

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Official Symbol
mttprovided by FlyBase
Official Full Name
mangetoutprovided by FlyBase
Primary source
FLYBASE:FBgn0050361
Locus tag
Dmel_CG30361
See related
AllianceGenome:FB:FBgn0050361
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0170980.4; anon-WO0170980.5; CG18447; CG30361; CG8692; Dmel\CG30361; DmGluBR; DmGluRB; DmXR; Glu-RB; GluRB; Mtt; mXr
Summary
Enables G protein-coupled receptor activity. Involved in adult feeding behavior; phospholipase C-activating G protein-coupled receptor signaling pathway; and response to insecticide. Located in dendrite and plasma membrane. Is expressed in gustatory receptor neurons; labellum; labral sense organ neurons; and organism subdivision. Used to study congenital stationary night blindness 1B. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See mtt in Genome Data Viewer
Location:
44D1-44D2; 2-59 cM
Exon count:
19
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8473956..8532294, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4361461..4419799, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Maltase A6 Neighboring gene Maltase A7 Neighboring gene Maltase A8 Neighboring gene long non-coding RNA:CR44279 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. NCD3G: a novel nine-cysteine domain in family 3 GPCRs. Liu X, et al. Trends Biochem Sci, 2004 Sep. PMID 15337118
  2. A Drosophila Model Reveals the Potential Role for mtt in Retinal Disease. Chen W, et al. Int J Mol Sci, 2024 Jan 11. PMID 38255972, Free PMC Article
  3. Molecular links between endocytosis and the actin cytoskeleton. Qualmann B, et al. J Cell Biol, 2000 Sep 4. PMID 10974009, Free PMC Article
  4. Gαo is required for L-canavanine detection in Drosophila. Devambez I, et al. PLoS One, 2013. PMID 23671680, Free PMC Article
  5. Plant insecticide L-canavanine repels Drosophila via the insect orphan GPCR DmX. Mitri C, et al. PLoS Biol, 2009 Jun 30. PMID 19564899, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Drosophila Model Reveals the Potential Role for mtt in Retinal Disease.
    Title: A Drosophila Model Reveals the Potential Role for mtt in Retinal Disease.
Submit: New GeneRIF Correction

General gene information

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Homology

mobile_element

  • Loc: c8477350-8477110 mobile_element_type = transposon:INE-1{}3542
  • Loc: c8492278-8490623 mobile_element_type = transposon:Rt1b{}779
  • Loc: c8529627-8529573 mobile_element_type = transposon:INE-1{}3558

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
NOT enables glutamate binding IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables glutamate binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
NOT enables glutamate receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adult feeding behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to insecticide IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to insecticide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mangetout
Names
CG30361-PC
CG30361-PD
CG30361-PE
CG30361-PF
CG30361-PG
DmX receptor
mXr
mtt-PC
mtt-PD
mtt-PE
mtt-PF
mtt-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    8473956..8532294 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136542.3 → NP_610386.2  mangetout, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610386.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7F4, Q70GQ8
    Conserved Domains (4) summary
    cd06362
    Location:73 → 527
    PBP1_mGluR; Ligand binding domain of the metabotropic glutamate receptors (mGluR)
    pfam00003
    Location:625 → 861
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:102 → 500
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:541 → 590
    NCD3G; Nine Cysteines Domain of family 3 GPCR

  2. NM_001144147.2 → NP_001137619.1  mangetout, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137619.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7YZT0
    Conserved Domains (5) summary
    cd06362
    Location:393 → 847
    PBP1_mGluR; Ligand binding domain of the metabotropic glutamate receptors (mGluR)
    pfam00003
    Location:945 → 1181
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:422 → 820
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:861 → 910
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cl10011
    Location:73 → 152
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

  3. NM_001273877.1 → NP_001260806.1  mangetout, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260806.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KF15
    Conserved Domains (5) summary
    cd06362
    Location:393 → 847
    PBP1_mGluR; Ligand binding domain of the metabotropic glutamate receptors (mGluR)
    pfam00003
    Location:945 → 1181
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:422 → 820
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:861 → 910
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cl10011
    Location:73 → 152
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

  4. NM_165609.3 → NP_724683.2  mangetout, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724683.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7F5, Q70GQ8
    Conserved Domains (4) summary
    cd06362
    Location:226 → 680
    PBP1_mGluR; Ligand binding domain of the metabotropic glutamate receptors (mGluR)
    pfam00003
    Location:778 → 1014
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:255 → 653
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:694 → 743
    NCD3G; Nine Cysteines Domain of family 3 GPCR

  5. NM_206058.2 → NP_995780.1  mangetout, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995780.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7F6
    Conserved Domains (3) summary
    pfam00003
    Location:310 → 546
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam07562
    Location:226 → 275
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cl10011
    Location:1 → 212
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KF15 A0A0B4KF15
A1Z7F4 A1Z7F4
A1Z7F5 A1Z7F5
A1Z7F6 A1Z7F6
B7YZT0 B7YZT0
Q70GQ8 Q70GQ8

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