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Mal-A8 Maltase A8 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35830, updated on 4-Jan-2025

Summary

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Official Symbol
Mal-A8provided by FlyBase
Official Full Name
Maltase A8provided by FlyBase
Primary source
FLYBASE:FBgn0033297
Locus tag
Dmel_CG8690
See related
AllianceGenome:FB:FBgn0033297
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8690; CT6532; Dmel\CG8690; Drome_A8; mal_A8
Summary
Predicted to enable alpha-1,4-glucosidase activity. Predicted to be involved in carbohydrate metabolic process. Is expressed in adult head. Human ortholog(s) of this gene implicated in cystinuria. Orthologous to human SLC3A1 (solute carrier family 3 member 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Mal-A8 in Genome Data Viewer
Location:
44D1-44D1; 2-59 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8471954..8473961)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4359459..4361466)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Maltase A6 Neighboring gene Maltase A7 Neighboring gene mangetout Neighboring gene long non-coding RNA:CR44279 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Association between duplicated maltase genes and the transcriptional regulation for the carbohydrate changes in Drosophila melanogaster. Inomata N, et al. Gene, 2019 Feb 20. PMID 30399425
  2. Differential gene expression by RNA-seq during Alzheimer's disease-like progression in the Drosophila melanogaster model. da Costa Silva JR, et al. Neurosci Res, 2022 Jul. PMID 35219723
  3. Assessment of genome-wide protein function classification for Drosophila melanogaster. Mi H, et al. Genome Res, 2003 Sep. PMID 12952880, Free PMC Article
  4. AMPK signaling linked to the schizophrenia-associated 1q21.1 deletion is required for neuronal and sleep maintenance. Nagy S, et al. PLoS Genet, 2018 Dec. PMID 30566533, Free PMC Article
  5. Transient adult microbiota, gut homeostasis and longevity: novel insights from the Drosophila model. Erkosar B, et al. FEBS Lett, 2014 Nov 17. PMID 24983497

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables alpha-1,4-glucosidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
maltase A8
Names
CG8690-PA
Mal-A8-PA
NP_610384.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    8471954..8473961
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136540.3 → NP_610384.1  maltase A8 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610384.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7F3, H5V882
    Related
    FBpp0087831
    Conserved Domains (3) summary
    cd11328
    Location:30 → 506
    AmyAc_maltase; Alpha amylase catalytic domain found in maltase (also known as alpha glucosidase) and related proteins
    TIGR02403
    Location:33 → 585
    trehalose_treC; alpha,alpha-phosphotrehalase
    cl02706
    Location:487 → 585
    Malt_amylase_C; Maltogenic Amylase, C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z7F3 A1Z7F3
Q8MS80 Q8MS80

Gene LinkOut

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