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CG2121 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35814, updated on 4-Jan-2025

Summary

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Official Symbol
CG2121provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0033289
Locus tag
Dmel_CG2121
See related
AllianceGenome:FB:FBgn0033289
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8698; Dmel\CG2121
Summary
Predicted to enable potassium channel regulator activity and transmembrane transporter activity. Involved in muscle contraction. Predicted to be active in plasma membrane and striated muscle dense body. Is expressed in adult head; embryonic somatic muscle cell; and larval somatic muscle cell. Orthologous to human UNC93A (unc-93 homolog A). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG2121 in Genome Data Viewer
Location:
44C4-44C6; 2-58 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8396397..8411767, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4283902..4299272, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene pou domain motif 3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene COP9 signalosome subunit 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CG4928 Is Vital for Renal Function in Fruit Flies and Membrane Potential in Cells: A First In-Depth Characterization of the Putative Solute Carrier UNC93A. Ceder MM, et al. Front Cell Dev Biol, 2020. PMID 33163493, Free PMC Article
  2. Sleep and wakefulness modulate gene expression in Drosophila. Cirelli C, et al. J Neurochem, 2005 Sep. PMID 16001966
  3. Control of daily transcript oscillations in Drosophila by light and the circadian clock. Wijnen H, et al. PLoS Genet, 2006 Mar. PMID 16565745, Free PMC Article
  4. Aβ42 Expressing Drosophila melanogaster Model for Alzheimer's Disease: Quantitative Proteomics Identifies Altered Protein Dynamics of Relevance to Neurodegeneration. Deolankar SC, et al. OMICS, 2022 Jan. PMID 35006003
  5. Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression. Perland E, et al. Open Biol, 2017 Sep. PMID 28878041, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in muscle contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of potassium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport ISM
Inferred from Sequence Model
more info
 PubMed 
Component Evidence Code Pubs
is_active_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in striated muscle dense body IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG2121-PA
CG2121-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    8396397..8411767 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001144146.2 → NP_001137618.1  uncharacterized protein Dmel_CG2121, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137618.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7YZU1
    Conserved Domains (2) summary
    pfam07690
    Location:296 → 476
    MFS_1; Major Facilitator Superfamily
    cl21472
    Location:84 → 189
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

  2. NM_136534.3 → NP_610378.1  uncharacterized protein Dmel_CG2121, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610378.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K3V9
    Related
    FBpp0087842
    Conserved Domains (2) summary
    pfam07690
    Location:282 → 462
    MFS_1; Major Facilitator Superfamily
    cl21472
    Location:70 → 175
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B7YZU1 B7YZU1
Q7K3V9 Q7K3V9

Gene LinkOut

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