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Cul4 Cullin 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35780, updated on 4-Jan-2025

Summary

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Official Symbol
Cul4provided by FlyBase
Official Full Name
Cullin 4provided by FlyBase
Primary source
FLYBASE:FBgn0033260
Locus tag
Dmel_CG8711
See related
AllianceGenome:FB:FBgn0033260
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8711; CRL4; cul-4; Cul-4; cul4; CUL4; Cullin4; dCul4; DMcul-4; Dmel\CG8711
Summary
Enables ubiquitin ligase complex scaffold activity. Involved in several processes, including chaeta morphogenesis; eggshell chorion gene amplification; and regulation of signal transduction. Located in nucleus. Part of Cul4-RING E3 ubiquitin ligase complex. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Cabezas type. Orthologous to several human genes including CUL4A (cullin 4A). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Cul4 in Genome Data Viewer
Location:
44A4-44A4; 2-58 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8102260..8106318, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3989765..3993823, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene sugar transporter 3 Neighboring gene sandman Neighboring gene univalents only Neighboring gene Transmembrane protein 63 Neighboring gene under-developed Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An E3 ubiquitin ligase, cullin-4 regulates retinal differentiation in Drosophila eye. Tare M, et al. Genesis, 2020 Nov. PMID 32990387, Free PMC Article
  2. BRWD3 promotes KDM5 degradation to maintain H3K4 methylation levels. Han D, et al. Proc Natl Acad Sci U S A, 2023 Sep 26. PMID 37722046, Free PMC Article
  3. Cell type-dependent requirement for PIP box-regulated Cdt1 destruction during S phase. Lee HO, et al. Mol Biol Cell, 2010 Nov 1. PMID 20826610, Free PMC Article
  4. Temporal remodeling of the cell cycle accompanies differentiation in the Drosophila germline. Hinnant TD, et al. Dev Biol, 2017 Sep 1. PMID 28711427, Free PMC Article
  5. Rbf1 degron dysfunction enhances cellular DNA replication. Raj N, et al. Cell Cycle, 2012 Oct 15. PMID 22895052, Free PMC Article

See all (111) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. An E3 ubiquitin ligase, cullin-4 regulates retinal differentiation in Drosophila eye.
    Title: An E3 ubiquitin ligase, cullin-4 regulates retinal differentiation in Drosophila eye.
  2. DCAF12 and Cul4 are critical for normal synaptic function and plasticity at larval neuromuscular junctions.
    Title: Cul4 ubiquitin ligase cofactor DCAF12 promotes neurotransmitter release and homeostatic plasticity.
  3. These studies provide insights into a novel role of cul-4 in promoting cell survival in the developing Drosophila eye.
    Title: Cullin-4 regulates Wingless and JNK signaling-mediated cell death in the Drosophila eye.
  4. BRWD3 functions as a Damage-specific DNA binding protein 1 (DDB1)- and CULLIN (CUL)4-associated factor in a Cullin4-RING Finger E3 Ligase (CRL4) that mediates light-dependent binding of dCRY to CUL4-ROC1-DDB1-BRWD3, inducing ubiquitylation of dCRY
    Title: Ramshackle (Brwd3) promotes light-induced ubiquitylation of Drosophila Cryptochrome by DDB1-CUL4-ROC1 E3 ligase complex.
  5. we could not detect Dup hyperaccumulation using mutations in the CRL4(Cdt2) components Cul4 and Ddb1, likely because these cause pleiotropic effects that block cell proliferation
    Title: Cell type-dependent requirement for PIP box-regulated Cdt1 destruction during S phase.
  6. Plays a conserved role in the regulation of beta-catenin levels.
    Title: Cullin4B/E3-ubiquitin ligase negatively regulates beta-catenin.
  7. loss of CUL4 in Drosophila cells causes G(1) cell cycle arrest and an increased protein level of the CDK inhibitor Dacapo
    Title: Involvement of CUL4 ubiquitin E3 ligases in regulating CDK inhibitors Dacapo/p27Kip1 and cyclin E degradation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin ligase complex scaffold activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chaeta morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in eggshell chorion gene amplification IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of hippo signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein polyubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IC
Inferred by Curator
more info
 PubMed 
involved_in protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul4-RING E3 ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cullin-RING ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cullin 4
Names
CG8711-PA
CG8711-PB
Cul4-PA
Cul4-PB
Cullin-4
Cullin4
cul-4
dCullin4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    8102260..8106318 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136508.4 → NP_610352.2  cullin 4, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610352.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5BI50
    Related
    FBpp0087897
    Conserved Domains (3) summary
    smart00182
    Location:503 → 644
    CULLIN; Cullin
    smart00884
    Location:750 → 815
    Cullin_Nedd8; Cullin protein neddylation domain
    pfam00888
    Location:124 → 721
    Cullin; Cullin family

  2. NM_001169613.1 → NP_001163084.1  cullin 4, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163084.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5BI50
    Conserved Domains (3) summary
    smart00182
    Location:503 → 644
    CULLIN; Cullin
    smart00884
    Location:750 → 815
    Cullin_Nedd8; Cullin protein neddylation domain
    pfam00888
    Location:124 → 721
    Cullin; Cullin family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5BI50 Q5BI50
Q961E0 Q961E0

Gene LinkOut

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