sand sandman [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: sandprovided by FlyBase
Official Full Name: sandmanprovided by FlyBase
Primary source: FLYBASE:FBgn0033257
Locus tag: Dmel_CG8713
See related: AllianceGenome:FB:FBgn0033257
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0109301.39; anon-WO0109301.40; anon-WO0109301.41; anon-WO0109301.42; anon-WO0109301.43; anon-WO0109301.44; anon-WO0109301.45; anon-WO0109301.46; anon-WO0109301.5; CG8713; Dmel\CG8713
Summary: Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Involved in cellular response to dopamine; negative regulation of circadian sleep/wake cycle, sleep; and negative regulation of membrane potential. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in embryonic esophagus; embryonic proventriculus; embryonic proventriculus inner layer; larval somatic muscle cell; and larval visceral muscle cell. Used to study epilepsy; heart conduction disease; and heart disease. Human ortholog(s) of this gene implicated in migraine. Orthologous to several human genes including KCNK18 (potassium two pore domain channel subfamily K member 18). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 44A4-44A4; 2-58 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (8091696..8096948)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (3979201..3984453)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of sandman, a K2P channel, recapitulates NCKX(zydeco) seizures. Indeed, sandman expression on cortex glial membranes is substantially reduced in NCKX(zydeco) mutants, indicating enhanced internalization of sandman predisposes animals to seizures.
Title: Glial Ca(2+)signaling links endocytosis to K(+) buffering around neuronal somas to regulate excitability.

Submit: New GeneRIF Correction

General gene information

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Markers

Dm0746 (e-PCR)
- UniSTS:52911

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables outward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel activity	IEA Inferred from Electronic Annotation more info
enables potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables potassium ion leak channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to dopamine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of circadian sleep/wake cycle, sleep	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info