cn cinnabar [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: cnprovided by FlyBase
Official Full Name: cinnabarprovided by FlyBase
Primary source: FLYBASE:FBgn0000337
Locus tag: Dmel_CG1555
See related: AllianceGenome:FB:FBgn0000337
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1555; Dmel\CG1555; Dmel\cn; KMO
Summary: Predicted to enable kynurenine 3-monooxygenase activity. Involved in kynurenine metabolic process. Predicted to be active in mitochondrial outer membrane. Is expressed in Malpighian tubule primordium; adult head; embryonic primordium of adult eye; epithelium; and yolk nucleus. Used to study amino acid metabolic disorder. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human KMO (kynurenine 3-monooxygenase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 43E16-43E16; 2-57 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (7782797..7785067, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (3670302..3672572, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A novel role for kynurenine 3-monooxygenase in mitochondrial dynamics.
Title: A novel role for kynurenine 3-monooxygenase in mitochondrial dynamics.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables FAD binding	IEA Inferred from Electronic Annotation more info
enables kynurenine 3-monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables kynurenine 3-monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables kynurenine 3-monooxygenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables kynurenine 3-monooxygenase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in NAD metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in compound eye pigmentation	TAS Traceable Author Statement more info	PubMed
involved_in kynurenine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in kynurenine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in quinolinate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in tryptophan catabolic process	IEA Inferred from Electronic Annotation more info
involved_in tryptophan catabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: cinnabar

Names: CG1555-PB; cn-PB; kynurenine 3-monooxygenase

NP_523651.4

EC 1.14.13.9

deletion mutation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

7782797..7785067 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078927.3 → NP_523651.4 cinnabar [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523651.4

Status: REVIEWED

UniProtKB/Swiss-Prot

A1Z746, Q27577, Q8SYV3, Q9BMM9

Conserved Domains (1) summary

COG0654
Location:31 → 411

UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]