U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dgat2 Diacylglycerol O-acyltransferase 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35719, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
Dgat2provided by FlyBase
Official Full Name
Diacylglycerol O-acyltransferase 2provided by FlyBase
Primary source
FLYBASE:FBgn0033215
Locus tag
Dmel_CG1942
See related
AllianceGenome:FB:FBgn0033215
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1942; DGAT; DGAT2; Dmel\CG1942
Summary
Predicted to enable diacylglycerol O-acyltransferase activity. Involved in lipid droplet organization. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including adult head; amnioserosa; plasmatocyte primordium; procrystal cell; and yolk nucleus. Human ortholog(s) of this gene implicated in metabolic dysfunction-associated steatotic liver disease. Orthologous to several human genes including MOGAT1 (monoacylglycerol O-acyltransferase 1); MOGAT2 (monoacylglycerol O-acyltransferase 2); and MOGAT3 (monoacylglycerol O-acyltransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Dgat2 in Genome Data Viewer
Location:
43E12-43E12; 2-57 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7712578..7714182)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3600083..3601687)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene torso Neighboring gene uncharacterized protein Neighboring gene mir-4909 stem loop Neighboring gene uncharacterized protein Neighboring gene Gdap2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Diurnal expression of Dgat2 induced by time-restricted feeding maintains cardiac health in the Drosophila model of circadian disruption. Guo Y, et al. Aging Cell, 2024 Jul. PMID 38616316, Free PMC Article
  2. Diverse biological processes coordinate the transcriptional response to nutritional changes in a Drosophila melanogaster multiparent population. Ng'oma E, et al. BMC Genomics, 2020 Jan 28. PMID 31992183, Free PMC Article
  3. Late-life shift in caloric intake affects fly metabolism and longevity. Li M, et al. Proc Natl Acad Sci U S A, 2023 Dec 12. PMID 38064506, Free PMC Article
  4. Determinants of Endoplasmic Reticulum-to-Lipid Droplet Protein Targeting. Olarte MJ, et al. Dev Cell, 2020 Aug 24. PMID 32730754, Free PMC Article
  5. Comparison of embryonic expression within multigene families using the FlyExpress discovery platform reveals more spatial than temporal divergence. Konikoff CE, et al. Dev Dyn, 2012 Jan. PMID 21960044, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables diacylglycerol O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables diacylglycerol O-acyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in lipid droplet organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mesoderm development NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in triglyceride biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
diacylglycerol O-acyltransferase 2
Names
CG1942-PA
Dgat2-PA
NP_610318.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    7712578..7714182
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136474.3 → NP_610318.1  diacylglycerol O-acyltransferase 2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610318.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K1C2
    Related
    FBpp0088002
    Conserved Domains (1) summary
    cl17185
    Location:74 → 340
    LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K1C2 Q7K1C2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous