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LRR Leucine-rich repeat [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35715, updated on 4-Jan-2025

Summary

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Official Symbol
LRRprovided by FlyBase
Official Full Name
Leucine-rich repeatprovided by FlyBase
Primary source
FLYBASE:FBgn0033212
Locus tag
Dmel_CG1399
See related
AllianceGenome:FB:FBgn0033212
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Carmil; CG1399; CG1576; Dmel\CG1399; Dmel\LRR
Summary
Involved in negative regulation of canonical NF-kappaB signal transduction and negative regulation of immune response. Located in muscle tendon junction. Is expressed in adult brain cell body rind and adult head. Human ortholog(s) of this gene implicated in immunodeficiency 58. Orthologous to several human genes including CARMIL1 (capping protein regulator and myosin 1 linker 1) and CARMIL3 (capping protein regulator and myosin 1 linker 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See LRR in Genome Data Viewer
Location:
43E9-43E11; 2-57 cM
Exon count:
24
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7676540..7698902, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3564045..3586407, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene U2A Neighboring gene uncharacterized protein Neighboring gene Coenzyme Q9 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Neonicotinoid clothianidin adversely affects insect immunity and promotes replication of a viral pathogen in honey bees. Di Prisco G, et al. Proc Natl Acad Sci U S A, 2013 Nov 12. PMID 24145453, Free PMC Article
  2. The Power of Drosophila melanogaster for Modeling Neonicotinoid Effects on Pollinators and Identifying Novel Mechanisms. Tasman K, et al. Front Physiol, 2021. PMID 33967830, Free PMC Article
  3. Disruption of the lipolysis pathway results in stem cell death through a sterile immunity-like pathway in adult Drosophila. Aggarwal P, et al. Cell Rep, 2022 Jun 21. PMID 35732115, Free PMC Article
  4. Combinatorial deployment of F-actin regulators to build complex 3D actin structures in vivo. Xie Y, et al. Elife, 2021 May 5. PMID 33949307, Free PMC Article
  5. The genetic basis of adaptation to copper pollution in Drosophila melanogaster. Everman ER, et al. Front Genet, 2023. PMID 37082199, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium assembly ISM
Inferred from Sequence Model
more info
 PubMed 
involved_in negative regulation of canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in muscle tendon junction IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Leucine-rich repeat
Names
CG1399-PA
CG1399-PB
CG1399-PC
CG1399-PD
CG1399-PF
CG1399-PG
LRR-PA
LRR-PB
LRR-PC
LRR-PD
LRR-PF
LRR-PG
dcarmil
leucine-rich repeat

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    7676540..7698902 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273859.1 → NP_001260788.1  Leucine-rich repeat, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260788.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KEE7
    Conserved Domains (4) summary
    cd00116
    Location:441 → 656
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:364 → 389
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:289 → 331
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam16000
    Location:797 → 1108
    CARMIL_C; CARMIL C-terminus

  2. NM_001169605.1 → NP_001163076.1  Leucine-rich repeat, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163076.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NND6
    Conserved Domains (1) summary
    pfam16000
    Location:4 → 114
    CARMIL_C; CARMIL C-terminus

  3. NM_001169606.2 → NP_001163077.2  Leucine-rich repeat, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163077.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JGZ7
    Conserved Domains (3) summary
    cd00116
    Location:420 → 635
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:343 → 368
    LRR_RI; leucine-rich repeat [structural motif]
    pfam16000
    Location:776 → 1080
    CARMIL_C; CARMIL C-terminus

  4. NM_001169604.2 → NP_001163075.1  Leucine-rich repeat, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163075.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JGZ8
    Conserved Domains (3) summary
    cd00116
    Location:420 → 635
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:343 → 368
    LRR_RI; leucine-rich repeat [structural motif]
    pfam16000
    Location:776 → 1080
    CARMIL_C; CARMIL C-terminus

  5. NM_136472.6 → NP_610316.3  Leucine-rich repeat, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610316.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z734
    Conserved Domains (3) summary
    cd00116
    Location:443 → 658
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:366 → 391
    LRR_RI; leucine-rich repeat [structural motif]
    pfam16000
    Location:799 → 1103
    CARMIL_C; CARMIL C-terminus

  6. NM_165549.4 → NP_724593.2  Leucine-rich repeat, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724593.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IGL5
    Related
    FBpp0088014
    Conserved Domains (1) summary
    pfam16000
    Location:51 → 306
    CARMIL_C; CARMIL C-terminus
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KEE7 A0A0B4KEE7
A1Z734 A1Z734
E1JGZ7 E1JGZ7
E1JGZ8 E1JGZ8
Q6NND6 Q6NND6
Q8IGL5 Q8IGL5

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