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Gpo2 Glycerophosphate oxidase 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35689, updated on 4-Jan-2025

Summary

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Official Symbol
Gpo2provided by FlyBase
Official Full Name
Glycerophosphate oxidase 2provided by FlyBase
Primary source
FLYBASE:FBgn0033190
Locus tag
Dmel_CG2137
See related
AllianceGenome:FB:FBgn0033190
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
146747_at; alpha-GPO; CG2137; Dmel\CG2137; Gpo; GPO; gpo-2; GPO-2
Summary
Enables glycerol-3-phosphate dehydrogenase (quinone) activity. Predicted to be involved in glycerol-3-phosphate metabolic process. Is active in mitochondrion. Is expressed in adult head. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human GPD2 (glycerol-3-phosphate dehydrogenase 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Gpo2 in Genome Data Viewer
Location:
43D3-43D3; 2-56 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7535919..7538297)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3423424..3425802)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Death resistor Adh domain containing target Neighboring gene long non-coding RNA:CR44209 Neighboring gene Cytochrome b5 Neighboring gene uncharacterized protein Neighboring gene corin Neighboring gene Ribulose-5-phosphate-3-epimerase Neighboring gene boca

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A genetic and molecular analysis of the alpha glycerophosphate cycle in Drosophila melanogaster. MacIntyre RJ, et al. Isozymes Curr Top Biol Med Res, 1987. PMID 3110096
  2. The -glycerophosphate cycle in Drosophila melanogaster. I. Biochemical and developmental aspects. O'Brien SJ, et al. Biochem Genet, 1972 Oct. PMID 4340553
  3. Regulation of sn-glycerol-3-phosphate dehydrogenase in Drosophila melanogaster larvae by dietary ethanol and sucrose. Geer BW, et al. J Nutr, 1983 Aug. PMID 6410023
  4. The biological basis of ethanol tolerance in Drosophila. Geer BW, et al. Comp Biochem Physiol B, 1993 Jun. PMID 8359013
  5. Macrophage mitochondrial bioenergetics and tissue invasion are boosted by an Atossa-Porthos axis in Drosophila. Emtenani S, et al. EMBO J, 2022 Jun 14. PMID 35319107, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables glycerol-3-phosphate dehydrogenase (quinone) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycerol-3-phosphate dehydrogenase (quinone) activity IEA
Inferred from Electronic Annotation
more info
  
enables glycerol-3-phosphate dehydrogenase (quinone) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in glycerol-3-phosphate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerol-3-phosphate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
glycerophosphate oxidase 2
Names
CG2137-PA
Gpo2-PA
alpha glycerophosphate oxidase 2
NP_610295.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    7535919..7538297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136451.1 → NP_610295.1  glycerophosphate oxidase 2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610295.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z707, Q6AWE4
    Related
    FBpp0087981, FBtr0088907
    Conserved Domains (5) summary
    PLN02464
    Location:8 → 583
    PLN02464; glycerol-3-phosphate dehydrogenase
    pfam13499
    Location:614 → 671
    EF-hand_7; EF-hand domain pair
    pfam16901
    Location:443 → 569
    DAO_C; C-terminal domain of alpha-glycerophosphate oxidase
    cl08302
    Location:614 → 672
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl21454
    Location:55 → 85
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z707 A1Z707

Gene LinkOut

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