pdha-1 Pyruvate dehydrogenase E1 component subunit alpha;putative pyruvate dehydrogenase E1 component subunit alpha, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pdha-1
Official Full Name: Pyruvate dehydrogenase E1 component subunit alpha;putative pyruvate dehydrogenase E1 component subunit alpha, mitochondrial
Primary source: WormBase:WBGene00011510
Locus tag: CELE_T05H10.6
See related: AllianceGenome:WB:WBGene00011510
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable pyruvate dehydrogenase (acetyl-transferring) activity. Predicted to be involved in acetyl-CoA biosynthetic process from pyruvate. Located in mitochondrion. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency and spermatogenic failure 70. Orthologous to human PDHA1 (pyruvate dehydrogenase E1 subunit alpha 1) and PDHA2 (pyruvate dehydrogenase E1 subunit alpha 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pdha-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 4

Sequence:: Chromosome: II; NC_003280.10 (8066287..8068184)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T05H10.6 (e-PCR)
- UniSTS:310687

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	IEA Inferred from Electronic Annotation more info
enables pyruvate dehydrogenase (acetyl-transferring) activity	IBA Inferred from Biological aspect of Ancestor more info
enables pyruvate dehydrogenase (acetyl-transferring) activity	IEA Inferred from Electronic Annotation more info
enables pyruvate dehydrogenase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acetyl-CoA biosynthetic process from pyruvate	IBA Inferred from Biological aspect of Ancestor more info
involved_in acetyl-CoA biosynthetic process from pyruvate	IEA Inferred from Electronic Annotation more info
involved_in pyruvate metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Pyruvate dehydrogenase E1 component subunit alpha;putative pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

NP_001379071.1

Confirmed by transcript evidence

NP_871953.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

8066287..8068184

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_182153.6 → NP_871953.1 Pyruvate dehydrogenase E1 component subunit alpha [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_871953.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8I111

Conserved Domains (1) summary

cl01629
Location:51 → 391

TPP_enzymes; Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and ...
NM_001393133.1 → NP_001379071.1 putative pyruvate dehydrogenase E1 component subunit alpha, mitochondrial [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

P52899

Conserved Domains (1) summary

cl01629
Location:34 → 374

TPP_enzymes; Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and ...