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lsy-12 Histone acetyltransferase lsy-12 [ Caenorhabditis elegans ]

Gene ID: 3565873, updated on 9-Dec-2024

Summary

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Official Symbol
lsy-12
Official Full Name
Histone acetyltransferase lsy-12
Primary source
WormBase:WBGene00045419
Locus tag
CELE_R07B5.9
See related
AllianceGenome:WB:WBGene00045419
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable chromatin binding activity; histone H4K16 acetyltransferase activity; and transcription coregulator activity. Involved in cell fate specification; maintenance of left/right asymmetry; and positive regulation of gene expression. Predicted to be located in chromatin. Predicted to be part of MSL complex; NSL complex; and NuA4 histone acetyltransferase complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See lsy-12 in Genome Data Viewer
Location:
chromosome: V
Exon count:
17
Sequence:
Chromosome: V; NC_003283.11 (9846157..9859963, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene Serpentine Receptor, class U Neighboring gene Serpentine Receptor, class U Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene pseudo Neighboring gene Serpentine Receptor, class AB (class A-like) Neighboring gene ncRNA Neighboring gene Serpentine Receptor, class AB (Class A-like) Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Comparing platforms for C. elegans mutant identification using high-throughput whole-genome sequencing. Shen Y, et al. PLoS One, 2008. PMID 19107202, Free PMC Article
  2. Maintenance of neuronal laterality in Caenorhabditis elegans through MYST histone acetyltransferase complex components LSY-12, LSY-13 and LIN-49. O'Meara MM, et al. Genetics, 2010 Dec. PMID 20923973, Free PMC Article
  3. Analysis of multiple ethyl methanesulfonate-mutagenized Caenorhabditis elegans strains by whole-genome sequencing. Sarin S, et al. Genetics, 2010 Jun. PMID 20439776, Free PMC Article
  4. Genetic screens for Caenorhabditis elegans mutants defective in left/right asymmetric neuronal fate specification. Sarin S, et al. Genetics, 2007 Aug. PMID 17717195, Free PMC Article
  5. Caenorhabditis elegans mutant allele identification by whole-genome sequencing. Sarin S, et al. Nat Methods, 2008 Oct. PMID 18677319, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3 acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptide-lysine-N-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in maintenance of left/right asymmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of MOZ/MORF histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Histone acetyltransferase lsy-12
NP_001256145.1
  • Partially confirmed by transcript evidence
NP_001256146.1
  • Confirmed by transcript evidence
NP_001256147.1
  • Partially confirmed by transcript evidence
NP_001263847.1
  • Partially confirmed by transcript evidence
NP_001263848.1
  • Confirmed by transcript evidence
NP_001263849.1
  • Partially confirmed by transcript evidence
NP_001359576.1
  • Confirmed by transcript evidence
NP_001360180.1
  • Confirmed by transcript evidence
NP_001368168.1
  • Confirmed by transcript evidence
NP_001379520.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    9846157..9859963 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001276920.4 → NP_001263849.1  Histone acetyltransferase lsy-12 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001263849.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D7SFM3, G5EBH5, G5EGP0, G5EGU3, K8ERR8, K8ES81, K8ESF3, K8F7U3, L8E6K3, Q21789
    Conserved Domains (2) summary
    pfam01853
    Location:605 → 786
    MOZ_SAS; MOZ/SAS family
    cl17182
    Location:550 → 783
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

  2. NM_001276918.3 → NP_001263847.1  Histone acetyltransferase lsy-12 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001263847.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    K8F7U3
    Conserved Domains (2) summary
    pfam01853
    Location:560 → 741
    MOZ_SAS; MOZ/SAS family
    cl17182
    Location:505 → 738
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

  3. NM_001373081.2 → NP_001360180.1  Histone acetyltransferase lsy-12 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (2) summary
    pfam01853
    Location:269 → 447
    MOZ_SAS; MOZ/SAS family
    pfam17772
    Location:211 → 264
    zf-MYST; MYST family zinc finger domain

  4. NM_001269216.3 → NP_001256145.1  Histone acetyltransferase lsy-12 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256145.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EGP0
    Conserved Domains (2) summary
    pfam01853
    Location:560 → 741
    MOZ_SAS; MOZ/SAS family
    cl17182
    Location:505 → 738
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

  5. NM_001269218.3 → NP_001256147.1  Histone acetyltransferase lsy-12 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256147.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EBH5
    Conserved Domains (2) summary
    pfam01853
    Location:605 → 786
    MOZ_SAS; MOZ/SAS family
    cl17182
    Location:550 → 783
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

  6. NM_001269217.3 → NP_001256146.1  Histone acetyltransferase lsy-12 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256146.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EGU3
    Conserved Domains (2) summary
    pfam01853
    Location:276 → 457
    MOZ_SAS; MOZ/SAS family
    cl17182
    Location:221 → 454
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

  7. NM_001276919.3 → NP_001263848.1  Histone acetyltransferase lsy-12 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001263848.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    K8ES81
    Conserved Domains (2) summary
    pfam01853
    Location:276 → 457
    MOZ_SAS; MOZ/SAS family
    cl17182
    Location:221 → 454
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

  8. NM_001392586.1 → NP_001379520.1  Histone acetyltransferase lsy-12 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (2) summary
    pfam01853
    Location:269 → 450
    MOZ_SAS; MOZ/SAS family
    pfam17772
    Location:211 → 264
    zf-MYST; MYST family zinc finger domain

  9. NM_001373082.2 → NP_001359576.1  Histone acetyltransferase lsy-12 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (2) summary
    pfam01853
    Location:269 → 447
    MOZ_SAS; MOZ/SAS family
    pfam17772
    Location:211 → 264
    zf-MYST; MYST family zinc finger domain

  10. NM_001380733.2 → NP_001368168.1  Histone acetyltransferase lsy-12 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (2) summary
    pfam01853
    Location:269 → 450
    MOZ_SAS; MOZ/SAS family
    pfam17772
    Location:211 → 264
    zf-MYST; MYST family zinc finger domain
Nucleotide Protein
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