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F13G3.10 Nascent polypeptide-associated complex subunit alpha-like UBA domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 3565846, updated on 2-Nov-2024

Summary

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Official Symbol
F13G3.10
Official Full Name
Nascent polypeptide-associated complex subunit alpha-like UBA domain-containing protein
Primary source
WormBase:WBGene00008768
Locus tag
CELE_F13G3.10
See related
AllianceGenome:WB:WBGene00008768
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in negative regulation of apoptotic process and protein stabilization. Orthologous to human HYPK (huntingtin interacting protein K). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See F13G3.10 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003279.8 (7313625..7314279, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Innexin eat-5 Neighboring gene MIF-like protein mif-3 Neighboring gene Uncharacterized protein Neighboring gene Guanine nucleotide-binding protein subunit beta-2 Neighboring gene Secreted protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Proteins in aggregates functionally impact multiple neurodegenerative disease models by forming proteasome-blocking complexes. Ayyadevara S, et al. Aging Cell, 2015 Feb. PMID 25510159, Free PMC Article
  2. Structural insights into pro-aggregation effects of C. elegans CRAM-1 and its human ortholog SERF2. Balasubramaniam M, et al. Sci Rep, 2018 Oct 5. PMID 30291272, Free PMC Article
  3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein stabilization IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Nascent polypeptide-associated complex subunit alpha-like UBA domain-containing protein
NP_001122452.1
  • Confirmed by transcript evidence
NP_001359719.1
  • Confirmed by transcript evidence
NP_001379130.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    7313625..7314279 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001373051.2 → NP_001359719.1  Nascent polypeptide-associated complex subunit alpha-like UBA domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ECM7
    Conserved Domains (1) summary
    cd14361
    Location:49 → 89
    UBA_HYPK; UBA-like domain found in Huntingtin-interacting protein K (HYPK) and similar proteins

  2. NM_001392546.1 → NP_001379130.1  Nascent polypeptide-associated complex subunit alpha-like UBA domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ECC1
    Conserved Domains (2) summary
    cd14361
    Location:54 → 94
    UBA_HYPK; UBA-like domain found in Huntingtin-interacting protein K (HYPK) and similar proteins
    pfam15921
    Location:6 → 95
    CCDC158; Coiled-coil domain-containing protein 158

  3. NM_001128980.4 → NP_001122452.1  Nascent polypeptide-associated complex subunit alpha-like UBA domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122452.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B2D6L9
    Conserved Domains (1) summary
    cl21463
    Location:1 → 30
    UBA_like_SF; UBA domain-like superfamily
Nucleotide Protein
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