magu-2 MAGUK p55 subfamily member 5 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: magu-2
Official Full Name: MAGUK p55 subfamily member 5
Primary source: WormBase:WBGene00006467
Locus tag: CELE_C01B7.4
See related: AllianceGenome:WB:WBGene00006467
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to be involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; morphogenesis of an epithelium; and protein localization to plasma membrane. Predicted to be located in axon and membrane. Predicted to be active in adherens junction and plasma membrane. Is expressed in head; hypodermis; intestine; and pharyngeal muscle cell. Orthologous to human PALS1 (protein associated with LIN7 1, MAGUK p55 family member). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See magu-2 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 11

Sequence:: Chromosome: V; NC_003283.11 (8792760..8801028, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C. elegans MAGU-2/Mpp5 homolog regulates epidermal phagocytosis and synapse density.
Title: C. elegans MAGU-2/Mpp5 homolog regulates epidermal phagocytosis and synapse density.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C01B7.4 (e-PCR)
- UniSTS:312145

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of polarity of embryonic epithelium	IBA Inferred from Biological aspect of Ancestor more info
involved_in generation of neurons	IBA Inferred from Biological aspect of Ancestor more info
involved_in morphogenesis of an epithelial sheet	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: MAGUK p55 subfamily member 5

NP_001355433.1

Confirmed by transcript evidence

NP_001379587.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

8792760..8801028 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001368460.3 → NP_001355433.1 MAGUK p55 subfamily member 5 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A3B1DQX2

Conserved Domains (4) summary

cd12036
Location:503 → 565

SH3_MPP5; Src Homology 3 domain of Membrane Protein, Palmitoylated 5 (or MAGUK p55 subfamily member 5)

smart00072
Location:642 → 817

GuKc; Guanylate kinase homologues

cd00136
Location:59 → 107

PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...

cd00992
Location:408 → 474

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_001392569.1 → NP_001379587.1 MAGUK p55 subfamily member 5 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q17549

Conserved Domains (3) summary

cd12036
Location:341 → 403

SH3_MPP5; Src Homology 3 domain of Membrane Protein, Palmitoylated 5 (or MAGUK p55 subfamily member 5)

smart00072
Location:480 → 655

GuKc; Guanylate kinase homologues

cd00992
Location:246 → 312

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...