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glo-1 Ras-related protein Rab [ Caenorhabditis elegans ]

Gene ID: 3565633, updated on 23-Jan-2025

Summary

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Official Symbol
glo-1
Official Full Name
Ras-related protein Rab
Primary source
WormBase:WBGene00011083
Locus tag
CELE_R07B1.12
See related
AllianceGenome:WB:WBGene00011083
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable GTPase activity. Involved in lipid storage and lysosome organization. Located in gut granule membrane. Is expressed in intestine. Orthologous to several human genes including RAB32 (RAB32, member RAS oncogene family). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See glo-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
5
Sequence:
Chromosome: X; NC_003284.9 (9872795..9882212, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene C6 domain-containing protein Neighboring gene Protein Upregulated in Glial Subsets Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Multidrug resistance-associated protein 1 Neighboring gene Solute carrier organic anion transporter family member Neighboring gene Methyltransf_21 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Neural Glyoxalase Pathway Enhancement by Morin Derivatives in an Alzheimer's Disease Model. Frandsen J, et al. ACS Chem Neurosci, 2020 Feb 5. PMID 31909963
  2. LYSMD proteins promote activation of Rab32-family GTPases for lysosome-related organelle biogenesis. Li J, et al. J Cell Biol, 2024 Oct 7. PMID 39078368, Free PMC Article
  3. Combinatorial Assembly of Modular Glucosides via Carboxylesterases Regulates C. elegans Starvation Survival. Wrobel CJJ, et al. J Am Chem Soc, 2021 Sep 15. PMID 34460264, Free PMC Article
  4. miR-51 regulates GABAergic synapses by targeting Rab GEF GLO-4 and lysosomal trafficking-related GLO/AP-3 pathway in Caenorhabditis elegans. Zhang S, et al. Dev Biol, 2018 Apr 1. PMID 29476722
  5. Characterization of HAF-4- and HAF-9-localizing organelles as distinct organelles in Caenorhabditis elegans intestinal cells. Tanji T, et al. BMC Cell Biol, 2016 Jan 27. PMID 26817689, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid storage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lysosome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in melanosome organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in gut granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in gut granule membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ras-related protein Rab
NP_001024837.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    9872795..9882212 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029666.3 → NP_001024837.1  Ras-related protein Rab [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024837.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EBF0
    Conserved Domains (2) summary
    smart00175
    Location:12 → 179
    RAB; Rab subfamily of small GTPases
    cd04107
    Location:12 → 212
    Rab32_Rab38; Rab GTPase families 18 (Rab18) and 32 (Rab32)
Nucleotide Protein
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