imb-3 Importin N-terminal domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: imb-3
Official Full Name: Importin N-terminal domain-containing protein
Primary source: WormBase:WBGene00002077
Locus tag: CELE_C53D5.6
See related: AllianceGenome:WB:WBGene00002077
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in protein import into nucleus. Predicted to be active in cytoplasm and nucleus. Orthologous to human RANBP6 (RAN binding protein 6) and IPO5 (importin 5). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See imb-3 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 7

Sequence:: Chromosome: I; NC_003279.8 (310981..314989, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C53D5.a (e-PCR)
- UniSTS:322516

C53D5.i (e-PCR)
- UniSTS:322519

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables nuclear import signal receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear localization sequence binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into nucleus	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Importin N-terminal domain-containing protein

NP_490715.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

310981..314989 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058314.7 → NP_490715.1 Importin N-terminal domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_490715.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9N5V3

Conserved Domains (3) summary

COG5215
Location:218 → 486

KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]

sd00044
Location:356 → 384

HEAT; HEAT repeat [structural motif]

pfam18808
Location:263 → 354

Importin_rep_4; Importin repeat