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mff-2 Mitochondrial fission factor [ Caenorhabditis elegans ]

Gene ID: 3565409, updated on 9-Dec-2024

Summary

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Official Symbol
mff-2
Official Full Name
Mitochondrial fission factor
Primary source
WormBase:WBGene00018894
Locus tag
CELE_F55F8.6
See related
AllianceGenome:WB:WBGene00018894
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in mitochondrial fission; positive regulation of mitochondrial fission; and positive regulation of protein targeting to membrane. Predicted to be located in mitochondrial outer membrane and peroxisome. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human MFF (mitochondrial fission factor). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mff-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
2
Sequence:
Chromosome: I; NC_003279.8 (5657917..5658712, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene CBF1-interacting co-repressor CIR N-terminal domain-containing protein Neighboring gene Ribosome biogenesis protein WDR12 homolog Neighboring gene Protein-tyrosine-phosphatase Neighboring gene SSD domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutations in Fis1 disrupt orderly disposal of defective mitochondria. Shen Q, et al. Mol Biol Cell, 2014 Jan. PMID 24196833, Free PMC Article
  2. Alcohol induces mitochondrial fragmentation and stress responses to maintain normal muscle function in Caenorhabditis elegans. Oh KH, et al. FASEB J, 2020 Jun. PMID 32294300, Free PMC Article
  3. Disruption of mitochondrial dynamics increases stress resistance through activation of multiple stress response pathways. Machiela E, et al. FASEB J, 2020 Jun. PMID 32385951, Free PMC Article
  4. The chromatin factors SET-26 and HCF-1 oppose the histone deacetylase HDA-1 in longevity and gene regulation in C. elegans. Emerson FJ, et al. Nat Commun, 2024 Mar 14. PMID 38485937, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in mitochondrial fission IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of mitochondrial fission IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein targeting to membrane IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mitochondrial fission factor
NP_001370753.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    5657917..5658712 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001383128.2 → NP_001370753.1  Mitochondrial fission factor [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    P91344
    Conserved Domains (1) summary
    pfam05644
    Location:105 → 160
    Miff; Mitochondrial and peroxisomal fission factor Mff
Nucleotide Protein
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