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cox-7C Cytochrome c oxidase polypeptide VIIc [ Caenorhabditis elegans ]

Gene ID: 3565338, updated on 4-Jan-2025

Summary

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Official Symbol
cox-7C
Official Full Name
Cytochrome c oxidase polypeptide VIIc
Primary source
WormBase:WBGene00009161
Locus tag
CELE_F26E4.6
See related
AllianceGenome:WB:WBGene00009161
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex IV. Orthologous to human COX7C (cytochrome c oxidase subunit 7C). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See cox-7C in Genome Data Viewer
Location:
chromosome: I
Exon count:
2
Sequence:
Chromosome: I; NC_003279.8 (9773172..9774012)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene putative peptidase C1-like protein F26E4.3 Neighboring gene Tyrosine-protein kinase Neighboring gene DNA-directed RNA polymerase III subunit RPC4 Neighboring gene ncRNA Neighboring gene FAS1 domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans. Rea SL, et al. PLoS Biol, 2007 Oct 2. PMID 17914900, Free PMC Article
  2. Caenorhabditis elegans mitochondrial mutants as an investigative tool to study human neurodegenerative diseases associated with mitochondrial dysfunction. Ventura N, et al. Biotechnol J, 2007 May. PMID 17443764
  3. Mitochondrial modulation of phosphine toxicity and resistance in Caenorhabditis elegans. Zuryn S, et al. Toxicol Sci, 2008 Mar. PMID 17998274
  4. Lifespan regulation by evolutionarily conserved genes essential for viability. Curran SP, et al. PLoS Genet, 2007 Apr 6. PMID 17411345, Free PMC Article
  5. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
Inferred from Electronic Annotation
more info
  
involved_in oxidative phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of respiratory chain complex IV IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Cytochrome c oxidase polypeptide VIIc
NP_492596.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    9773172..9774012
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060195.7 → NP_492596.2  Cytochrome c oxidase polypeptide VIIc [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492596.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O18687
    Conserved Domains (1) summary
    cl02797
    Location:46 → 81
    Cyt_c_Oxidase_VIIc; Cytochrome c oxidase subunit VIIc. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
Nucleotide Protein
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