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T04A8.7 1,4-alpha-glucan branching enzyme [ Caenorhabditis elegans ]

Gene ID: 3565201, updated on 2-Nov-2024

Summary

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Official Symbol
T04A8.7
Official Full Name
1,4-alpha-glucan branching enzyme
Primary source
WormBase:WBGene00011409
Locus tag
CELE_T04A8.7
See related
AllianceGenome:WB:WBGene00011409
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable 1,4-alpha-glucan branching enzyme activity. Predicted to be involved in glycogen biosynthetic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in glycogen storage disease IV and pulmonary tuberculosis. Orthologous to human GBE1 (1,4-alpha-glucan branching enzyme 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See T04A8.7 in Genome Data Viewer
Location:
chromosome: III
Exon count:
6
Sequence:
Chromosome: III; NC_003281.10 (4695357..4698014)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Amidophosphoribosyltransferase Neighboring gene RRM domain-containing protein Neighboring gene Rad60/SUMO-like domain-containing protein Neighboring gene J domain-containing protein Neighboring gene Zinc finger protein 830

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways. Duchaine TF, et al. Cell, 2006 Jan 27. PMID 16439208
  2. A global analysis of genetic interactions in Caenorhabditis elegans. Byrne AB, et al. J Biol, 2007. PMID 17897480, Free PMC Article
  3. A protein domain-based interactome network for C. elegans early embryogenesis. Boxem M, et al. Cell, 2008 Aug 8. PMID 18692475, Free PMC Article
  4. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
  5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 1,4-alpha-glucan branching enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1,4-alpha-glucan branching enzyme activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables cation binding IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycogen biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
1,4-alpha-glucan branching enzyme
NP_497961.1
  • Confirmed by transcript evidence
NP_871631.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    4695357..4698014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_181902.3 → NP_871631.1  1,4-alpha-glucan branching enzyme [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_871631.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86G92
    Conserved Domains (1) summary
    PLN02447
    Location:11 → 606
    PLN02447; 1,4-alpha-glucan-branching enzyme

  2. NM_065560.7 → NP_497961.1  1,4-alpha-glucan branching enzyme [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497961.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q22137
    Conserved Domains (1) summary
    PLN02447
    Location:1 → 681
    PLN02447; 1,4-alpha-glucan-branching enzyme
Nucleotide Protein
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