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deg-3 Acetylcholine receptor subunit alpha-type deg-3 [ Caenorhabditis elegans ]

Gene ID: 3565200, updated on 4-Jan-2025

Summary

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Official Symbol
deg-3
Official Full Name
Acetylcholine receptor subunit alpha-type deg-3
Primary source
WormBase:WBGene00000951
Locus tag
CELE_K03B8.9
See related
AllianceGenome:WB:WBGene00000951
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable excitatory extracellular ligand-gated monoatomic ion channel activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Involved in positive regulation of locomotion involved in locomotory behavior and regulation of programmed cell death. Predicted to be located in postsynaptic membrane. Predicted to be part of transmembrane transporter complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in ganglia and mechanosensory neurons. Used to study neurodegenerative disease. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See deg-3 in Genome Data Viewer
Location:
chromosome: V
Exon count:
8
Sequence:
Chromosome: V; NC_003283.11 (11412870..11415159, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Ground-like domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA-Val Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Acetylcholine receptor DES-2-like protein;Acetylcholine receptor subunit alpha-type des-2 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A mutated acetylcholine receptor subunit causes neuronal degeneration in C. elegans. Treinin M, et al. Neuron, 1995 Apr. PMID 7718248
  2. The Caenorhabditis elegans DEG-3/DES-2 Channel Is a Betaine-Gated Receptor Insensitive to Monepantel. Hansen TVA, et al. Molecules, 2022 Jan 5. PMID 35011544, Free PMC Article
  3. Characterization of the deg-3/des-2 receptor: a nicotinic acetylcholine receptor that mutates to cause neuronal degeneration. Yassin L, et al. Mol Cell Neurosci, 2001 Mar. PMID 11273652
  4. Mutations in the extracellular domain and in the membrane-spanning domains interfere with nicotinic acetylcholine receptor maturation. Yassin L, et al. Biochemistry, 2002 Oct 15. PMID 12369821
  5. Caenorhabditis elegans nicotinic acetylcholine receptors are required for nociception. Cohen E, et al. Mol Cell Neurosci, 2014 Mar. PMID 24518198, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The conserved residues in the second RIC-3 transmembrane domain are needed for its interactions with DEG-3,DES-2 and ACR-16.
    Title: Receptor and subunit specific interactions of RIC-3 with nicotinic acetylcholine receptors.
  2. subunit-specific interactions of RIC-3 with nAChR subunits DEG-3/DES-2, mediated by the transmembrane domains, are sufficient for the effects of RIC-3 on nAChR quantity and quality
    Title: RIC-3 affects properties and quantity of nicotinic acetylcholine receptors via a mechanism that does not require the coiled-coil domains.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables extracellular ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of locomotion involved in locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
part_of transmembrane transporter complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Acetylcholine receptor subunit alpha-type deg-3
NP_001379138.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    11412870..11415159 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392614.1 → NP_001379138.1  Acetylcholine receptor subunit alpha-type deg-3 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P54244
    Conserved Domains (3) summary
    cd19051
    Location:267 → 357
    LGIC_TM_cation; transmembrane domain of Cys-loop neurotransmitter-gated ion channels, includes 5HT3, nAChR, and ZAC
    pfam02931
    Location:53 → 266
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:273 → 543
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54244.1

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