flad-1 FAD synthase;Molybdenum cofactor biosynthesis protein-like region [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: flad-1
Official Full Name: FAD synthase;Molybdenum cofactor biosynthesis protein-like region
Primary source: WormBase:WBGene00011271
Locus tag: CELE_R53.1
See related: AllianceGenome:WB:WBGene00011271
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable FMN adenylyltransferase activity. Predicted to be involved in FAD biosynthetic process. Orthologous to human FLAD1 (flavin adenine dinucleotide synthetase 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See flad-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 8

Sequence:: Chromosome: II; NC_003280.10 (9944137..9947121)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mimicking human riboflavin responsive neuromuscular disorders by silencing flad-1 gene in C. elegans: Alteration of vitamin transport and cholinergic transmission.
Title: Mimicking human riboflavin responsive neuromuscular disorders by silencing flad-1 gene in C. elegans: Alteration of vitamin transport and cholinergic transmission.
study describes the structure and expression of the FADS gene and provides an overview of the effects of partially silencing the gene
Title: Silencing of FAD synthase gene in Caenorhabditis elegans upsets protein homeostasis and impacts on complex behavioral patterns.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R53.1 (e-PCR)
- UniSTS:321651

C05C10.6 (e-PCR)
- UniSTS:321186

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables FMN adenylyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables FMN adenylyltransferase activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in FAD biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in FAD biosynthetic process	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: FAD synthase;Molybdenum cofactor biosynthesis protein-like region

NP_001022286.1

Confirmed by transcript evidence

NP_001022287.1

Confirmed by transcript evidence

NP_001254233.1

Confirmed by transcript evidence

NP_001254234.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

9944137..9947121

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027115.3 → NP_001022286.1 Molybdenum cofactor biosynthesis protein-like region [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022286.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q22017, Q58AA6

Conserved Domains (3) summary

COG1058
Location:14 → 273

CinA; Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]

cd00885
Location:15 → 190

cinA; Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of ...

pfam01507
Location:328 → 485

PAPS_reduct; Phosphoadenosine phosphosulfate reductase family
NM_001027116.5 → NP_001022287.1 Molybdenum cofactor biosynthesis protein-like region [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022287.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q22017

Conserved Domains (3) summary

COG1058
Location:5 → 264

CinA; Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]

cd00885
Location:6 → 181

cinA; Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of ...

pfam01507
Location:319 → 476

PAPS_reduct; Phosphoadenosine phosphosulfate reductase family
NM_001267304.3 → NP_001254233.1 FAD synthase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254233.1

Status: REVIEWED

UniProtKB/TrEMBL

I2HAD4

Conserved Domains (1) summary

pfam01507
Location:227 → 384

PAPS_reduct; Phosphoadenosine phosphosulfate reductase family
NM_001267305.3 → NP_001254234.1 FAD synthase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254234.1

Status: REVIEWED

UniProtKB/TrEMBL

I2HAD5

Conserved Domains (1) summary

pfam01507
Location:180 → 337

PAPS_reduct; Phosphoadenosine phosphosulfate reductase family