kel-8 BACK domain-containing protein;BTB domain-containing protein;Kelch-like protein 8 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: kel-8
Official Full Name: BACK domain-containing protein;BTB domain-containing protein;Kelch-like protein 8
Primary source: WormBase:WBGene00020952
Locus tag: CELE_W02G9.2
See related: AllianceGenome:WB:WBGene00020952
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Located in neuron projection; neuronal cell body; and postsynaptic density. Part of Cul3-RING ubiquitin ligase complex. Is expressed in intestine and neurons. Orthologous to human KLHL8 (kelch like family member 8). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See kel-8 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 7

Sequence:: Chromosome: V; NC_003283.11 (2671455..2688499)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KEL-8 is a substrate receptor for Cullin 3 ubiquitin ligases that is required for the proteolysis of GLR-1 receptors and suggest a novel postmitotic role in neurons for Kelch/CUL3 ubiquitin ligases.
Title: KEL-8 is a substrate receptor for CUL3-dependent ubiquitin ligase that regulates synaptic glutamate receptor turnover.
cullin (CUL)-3 as a component of E3 ligase and KEL-8 as the substrate adaptor of RPY-1.
Title: Control of rapsyn stability by the CUL-3-containing E3 ligase complex.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

W02G9.2 (e-PCR)
- UniSTS:311097

W02G9.3 (e-PCR)
- UniSTS:306854

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ubiquitin-like ligase-substrate adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Cul3-RING ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: BACK domain-containing protein;BTB domain-containing protein;Kelch-like protein 8

NP_001300209.1

Confirmed by transcript evidence

NP_001300210.1

Confirmed by transcript evidence

NP_503729.4

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

2671455..2688499

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_071328.9 → NP_503729.4 Kelch-like protein 8 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_503729.4

Status: REVIEWED

UniProtKB/Swiss-Prot

G5ED84

Conserved Domains (6) summary

smart00612
Location:526 → 571

Kelch; Kelch domain

smart00875
Location:213 → 312

BACK; BTB And C-terminal Kelch

PHA03098
Location:111 → 598

PHA03098; kelch-like protein; Provisional

sd00038
Location:467 → 510

Kelch; KELCH repeat [structural motif]

pfam00651
Location:104 → 204

BTB; BTB/POZ domain

pfam01344
Location:560 → 605

Kelch_1; Kelch motif
NM_001313280.3 → NP_001300209.1 BTB domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AY66

Conserved Domains (3) summary

smart00612
Location:656 → 698

Kelch; Kelch domain

PHA03098
Location:148 → 635

PHA03098; kelch-like protein; Provisional

sd00038
Location:504 → 547

Kelch; KELCH repeat [structural motif]
NM_001313281.3 → NP_001300210.1 BACK domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3ASX2

Conserved Domains (3) summary

smart00612
Location:427 → 469

Kelch; Kelch domain

PHA03098
Location:1 → 406

PHA03098; kelch-like protein; Provisional

sd00038
Location:275 → 318

Kelch; KELCH repeat [structural motif]