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plst-1 Calponin-homology (CH) domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 3564941, updated on 2-Nov-2024

Summary

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Official Symbol
plst-1
Official Full Name
Calponin-homology (CH) domain-containing protein
Primary source
WormBase:WBGene00022425
Locus tag
CELE_Y104H12BR.1
See related
AllianceGenome:WB:WBGene00022425
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in actin filament bundle assembly. Is expressed in hypodermis; intestine; and pharynx. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 76; congenital diaphragmatic hernia; and nicotine dependence. Orthologous to human LCP1 (lymphocyte cytosolic protein 1); PLS1 (plastin 1); and PLS3 (plastin 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See plst-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
5
Sequence:
Chromosome: IV; NC_003282.8 (1289627..1296897)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene C-type lectin domain-containing protein Neighboring gene 30S ribosomal protein S15;DNA_pol_B_exo1 domain-containing protein;Transposase;Uncharacterized protein Neighboring gene ATP-dependent RNA helicase;Pre-mRNA-processing ATP-dependent RNA helicase PRP5;RNA helicase Neighboring gene PHD-type domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. β-heavy-spectrin stabilizes the constricting contractile ring during cytokinesis. Silva AM, et al. J Cell Biol, 2023 Jan 2. PMID 36219157, Free PMC Article
  2. Syncytial germline architecture is actively maintained by contraction of an internal actomyosin corset. Priti A, et al. Nat Commun, 2018 Nov 8. PMID 30410005, Free PMC Article
  3. Plastin increases cortical connectivity to facilitate robust polarization and timely cytokinesis. Ding WY, et al. J Cell Biol, 2017 May 1. PMID 28400443, Free PMC Article
  4. Neuron-specific knock-down of SMN1 causes neuron degeneration and death through an apoptotic mechanism. Gallotta I, et al. Hum Mol Genet, 2016 Jun 15. PMID 27260405, Free PMC Article
  5. Genetic modifiers ameliorate endocytic and neuromuscular defects in a model of spinal muscular atrophy. Walsh MB, et al. BMC Biol, 2020 Sep 16. PMID 32938453, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the evolutionarily conserved actin bundling/cross-linking protein plastin is instrumental for the generation of potent cortical actomyosin contractility in the Caenorhabditis elegans zygote
    Title: Plastin increases cortical connectivity to facilitate robust polarization and timely cytokinesis.
  2. We show that genes of the classical apoptosis pathway are involved in the smn-1-mediated neuronal death, and that this phenotype can be rescued by the expression of human SMN1, indicating a functional conservation between the two orthologs. Finally, we determined that Plastin3/plst-1 genetically interacts with smn-1 to prevent degeneration, and that treatment with valproic acid is able to rescue the degenerative phenotype
    Title: Neuron-specific knock-down of SMN1 causes neuron degeneration and death through an apoptotic mechanism.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin filament bundle assembly IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Calponin-homology (CH) domain-containing protein
NP_001294438.1
  • Confirmed by transcript evidence
NP_001294439.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    1289627..1296897
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001307510.2 → NP_001294439.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294439.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PMA7
    Conserved Domains (2) summary
    smart00033
    Location:246 → 348
    CH; Calponin homology domain
    pfam00307
    Location:1 → 94
    CH; Calponin homology (CH) domain

  2. NM_001307509.2 → NP_001294438.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294438.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PBU8
    Conserved Domains (2) summary
    smart00033
    Location:243 → 345
    CH; Calponin homology domain
    pfam00307
    Location:1 → 94
    CH; Calponin homology (CH) domain
Nucleotide Protein
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