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tbc-10 Rab-GAP TBC domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 3564790, updated on 9-Dec-2024

Summary

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Official Symbol
tbc-10
Official Full Name
Rab-GAP TBC domain-containing protein
Primary source
WormBase:WBGene00019915
Locus tag
CELE_R06B10.5
See related
AllianceGenome:WB:WBGene00019915
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in retrograde transport, endosome to Golgi. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including hypodermis; intestine; nervous system; pharynx; and vulval muscle. Orthologous to several human genes including TBC1D10A (TBC1 domain family member 10A) and TBC1D10C (TBC1 domain family member 10C). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See tbc-10 in Genome Data Viewer
Location:
chromosome: III
Exon count:
7
Sequence:
Chromosome: III; NC_003281.10 (983261..988446)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene Transient receptor ion channel domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene C-type lectin domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Epidermal control of axonal attachment via β-spectrin and the GTPase-activating protein TBC-10 prevents axonal degeneration. Coakley S, et al. Nat Commun, 2020 Jan 9. PMID 31919407, Free PMC Article
  2. The small GTPase RAB-35 facilitates the initiation of phagosome maturation and acts as a robustness factor for apoptotic cell clearance. Haley R, et al. Small GTPases, 2021 May. PMID 31607221, Free PMC Article
  3. The small GTPase RAB-35 defines a third pathway that is required for the recognition and degradation of apoptotic cells. Haley R, et al. PLoS Genet, 2018 Aug. PMID 30138370, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Rab-GAP TBC domain-containing protein
NP_497310.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    983261..988446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064909.5 → NP_497310.2  Rab-GAP TBC domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497310.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O44873
    Conserved Domains (1) summary
    smart00164
    Location:171 → 380
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
Nucleotide Protein
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